TThe purpose of this Program Announcement (PA) is to solicit applications to expand research on established self-management interventions to multiple chronic diseases across the life-course. Interventions aimed at chronic disease self-management are numerous and many are well described in the literature. They are often presented as specific to a particular chronic disease. This PA encourages applicants to investigate the applicability of effective self-management interventions to a broader spectrum of chronic diseases. Chronic disease, for this announcement, is defined as illnesses that are prolonged, are rarely cured completely, and require self-management behaviors by affected individuals and/or their caretakers.