The purpose of this Notice is to indicate the intent to issue a Request for Applications (RFA) for the 2010 NIH Director’s Pioneer Award Program. It is also intended to alert prospective applicants of important changes to the application and review process. This RFA will utilize the DP1 mechanism. Pre-applications (X02) will no longer be required. The RFA is expected to be published in the NIH Guide for Grants and Contracts in August 2009 with an anticipated application receipt date of October 20, 2009.