The Office of Rare Diseases, National Institutes of Health, will host a public pre-application meeting for investigators planning to submit applications in response to the Request for Applications (RFA) OD-08-001, entitled "Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (U54)” (http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-08-001.html) or RFA OD-08-002, entitled Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Network (U54) " (http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-08-002.html ). The Rare Diseases Clinical Research Network program will facilitate identification of biomarkers for disease risk, disease severity/activity, and measures of clinical outcomes appropriate for applicability to clinical trialsand encourage development of new approaches to diagnosis, prevention, and treatment of rare diseases