Hurricane Isabel has led to the closure of institutions on the East Coast and the Federal government in the Washington, D.C. area. The NIH realizes that this may cause problems for investigators who are planning on submitting grant applications. Applications that are submitted late because of problems caused by Hurricane Isabel should include a cover letter noting the reasons for the delay. It is not necessary to get permission in advance for hurricane-related delays in grant application submission. It is expected that the delay will generally not exceed the time period that an institution is closed.