This Notice informs potential applicants that, effective immediately, the National Institute of Neurological Disorders and Stroke (NINDS) will no longer accept applications under PAR-10-001, "Drug Discovery for Nervous System Disorders (R01)," beginning with the February 5, 2012 receipt date. Researchers seeking support for chemical optimization of small molecules probes for preclinical, in vivo proof-of-concept experiments for the purposes of drug discovery should consider PAR-12-060, "Solicitation of Validated Hits for the Discovery of in vivo Chemical Probes (R01)."