The purpose of this Notice is to inform NINDS grant applicants that, beginning with applications submitted for the June 5, 2012 submission date, NINDS will not accept unsolicited R01 applications which include clinical trials of potential therapies under the NIH parent R01 Funding Opportunity Announcement (FOA) PA-11-260 and subsequent revisions to this FOA. A clinical trial is a prospective biomedical or behavioral research study of human subjects that is designed to answer specific questions about pharmacologic, behavioral, biologic, surgical, or device interventions.