This is a time-sensitive Request for Information (RFI) issued by the National Institute of Neurological Disorders and Stroke. The purpose of this RFI is to solicit recommendations on the best practices for animal studies on Huntington’s disease that could advance knowledge and validation of therapeutic targets for disease treatment. The Institute envisions that standardization of animal studies through identification of common protocols, outcome measures and breeding practices will enable comparison of results across studies and targets. Best practice guidelines should be inclusive of in vivo target manipulation through either genetic or pharmacological interventions. The responses to the RFI will be collected and evaluated by a group of Institute staff to assess how best to meet the needs of researchers in the field. Results of that evaluation will be made available to the public and will be part of a larger effort by NINDS to develop best practice guidelines for target discovery and validation for neurological diseases.