The purpose of this notice is to announce that the NINDS is seeking experienced medicinal chemists to provide small molecule design support to investigators applying to the Research Funding Announcement NS-09-003, entitled; “Optimization of Small Molecule Probes for the Nervous System” (R21). It is expected that medicinal chemistry planning will be included as part of a successful project proposal. Chemistry expertise will be needed to help design and evaluate small molecule analogues in support of structure-activity relationship studies and compound optimization. NINDS, and other NIH Institutes participating in the Program (NIAAA, NIDA), acknowledge the importance of having medicinal chemistry input to the small molecule design and optimization required of this Program, and will therefore support funding allowance within proposals responding to RFA-NS-09-003 for attaining such expertise. Applicants to this Program that do not presently have access to such a resource will be able to choose from a listing that will be provided upon request by the Program Director, of qualified medicinal chemists that are willing to provide support as an active participant in the proposed studies. As it is expected that compound acquisition in this Program will be substantially guided by external procurement using available cheminformatic tools the consultant services described in this notice will not require the provision of chemical synthesis support.