The UC Davis/NINDS/NIMH NeuroMab facility (http://www.neuromab.org) has been established to generate and distribute, at low cost to neuroscientist end users, high-quality, validated mouse monoclonal antibodies against molecular targets found in the nervous system (NeuroMabs). NeuroMabs are suitable for 1) protein localization studies in the adult, developing and pathological nervous system, 2) biochemical analyses of subunit composition and post-translational modifications of native nervous system proteins, and 3) proteomic analyses of native nervous system protein networks.