This Notice announces a joint initiative, Collaborative Research in Computational Neuroscience (CRCNS), between five National Science Foundation (NSF) Directorates and nine participating National Institutes of Health (NIH) Institutes. The CRCNS announcement is released under NSF 04-514, http://www.nsf.gov/cgi-bin/getpub?nsf04514. This announcement supersedes NSF 02-018; Support Collaborative Research in Computational Neuroscience (CRCNS). This new announcement differs from the prior issuance in that it is effect for three years, and the scope of the solicitation is expanded to include the interests of other NIH Institutes and NSF Directorates.