The goal of this program is to open critical paths in pre-clinical therapeutics development by funding small, focused projects. Supported studies should be designed to demonstrate the promise of therapies to 1) reduce the barriers to commercial development or 2) justify NIH funding for additional pre-clinical or clinical development. Thus, proposals should demonstrate both a sound rationale for the proposed project and a feasible plan to support further development of the candidate therapy. The proposed intervention(s) should have clearly demonstrated promise as treatments for neurological disease based on data from previous in vitro, animal or clinical testing. Highest funding priority will be given to studies that are specifically designed to support an IND application for clinical testing, and that form part of a well-developed plan for pursuing an IND.