The National Institute of Neurological Disorders and Stroke (NINDS) has the stated mission to reduce the burden of neurological disease—a burden borne by every age group, by every segment of society, by people all over the world. Within this mission falls gene discovery. Gene discovery elucidates the cause of some diseases, and also, the underlying pathogenesis of related disorders. Genetic studies of neurological disorders are increasing in number and complexity. Such studies require a large and diverse sample and accompanying information base. Thus, a repository of DNA samples, immortalized cell lines (from which DNA can be extracted continuously), and accompanying clinical and pedigree data is clearly an invaluable resource for the neuroscience community. This project is conceptually related to repositories in existence at other institutes at the NIH.