This Notice announces a joint initiative between the National Science Foundation (NSF) and seven participating National Institute of Health (NIH) Institutes to support interdisciplinary research in computational neuroscience. Both agencies recognize the need for research that focuses on integrating computational models and methods with neuroscience. This solicitation is designed to encourage new and existing collaborations at this interface. Appropriate scientific areas of investigations are those that are currently supported by NSF and NIH, or related to the missions of the two agencies.