The SCORE (Support of Competitive Research) Program is a developmental program designed to increase the research competitiveness of faculty at minority-serving institutions (MSIs) and the research capabilities of MSIs. To better achieve these objectives, the SCORE program has been revised so that separate funding opportunities exist for individual investigator-initiated research awards and for a stand-alone institutional award. The mechanisms used for these funding opportunities are the SC1, SC2 and SC3 awards for individual investigators and the S06 award for institutions. SC1 ( PAR-06-492 ) and SC2 ( PAR-06-493 ) applications will be assigned to NIGMS with secondary assignments to the above listed Institutes according to the research topic of the application based on standard NIH receipt and referral guidelines. Each Institute maintains a website with funding opportunities and areas of interest. Applicants are advised to visit these Websites and to contact Institute representatives to help develop their research plan consistent with the mission of that IC. For further information, see http://www.nih.gov/icd , which provides a brief summary of the research interests of each Institute and access to individual Institute home pages.