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Neural Environment

Neurological disorders may result when extra-neuronal cells are compromised, as in demyelinating and cerebrovascular diseases; when extra-neuronal cells themselves become aggressors, as in inflammatory responses within the nervous system; when cells of the nervous system become cancerous and form tumors; when viruses, bacteria, or parasites infect the cells of the nervous system; when autoimmune responses damage nerve and muscle; when cells of the blood-brain barrier are dysfunctional, or when glial dysfunction in the developing nervous system results in developmental abnormalities. Glial cells, microvascular endothelia, and cells of hematopoetic origin are integrally involved in the normal development and/or functioning of the nervous system and play a crucial role in disease. Emerging concepts on the interaction among all of these cells hold great promise for increasing our understanding of how the nervous system works in normal and diseased states, and will broaden our perspective on how we think about the nervous system.

The Neural Environment program area promotes translating scientific knowledge into useful diagnostic tools, research on the implementation of preventive measures, and development and delivery of targeted therapeutic agents for neurological diseases.

More Information on the Neural Environment program area.

Funding Initiatives in this category: