NINDS Translational Cooperative Agreement Program

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Disorder	Modality	Title	PI	Institution	IND/IDE Anticipated
Alzheimer's	vaccine	A Therapeutic DNA Epitope Vaccine for Alzheimer's Disease	Evans, Claire	Ichor Medical Systems, Inc.	2013
lysosomal storage disorder	gene therapy	AAV-Mediated Gene Therapy for GM2-Gangliodoses	Esteves, Miquel	Univ of Massachusetts Med Sch Worcester	2013
insecticide poisoning	enzyme	Aerosol Delivery of a Recombinant Butyrylcholinesterase "Bioshield" to Protect AG	Rosenberg, Yvonne	Plantvax, Inc.	2013
muscular dystrophy	gene therapy	Antisense Oligonucleotide Treatment for Myotonic Dystrophy	Thornton, Charles A.	University of Rochester	2015
muscular dystrophy	gene therapy	Antisense Therapy for DMD-Optimization and Toxicology of AON for EXON 45 Skipping	Lu, Qi	Carolinas Medical Center	2014
frontotemporal lobar degeneration	drug	Development and Testing of HSP90 Inhibitors	Petrucelli, Leonard	Mayo Clinic Jacksonville	2015
epilepsy	peptide	Development of a Galanin-Based Therapy for the Treatment of Refractory Epilepsy	White, Steve	University of Utah	2015
Alzheimer's	drug	Development of an Agonist of the TGF-Beta Signaling Pathway to Treat Alzheimer's	Wyss-Coray, Tony	Palo Alto Institute for Res & Edu, Inc.	2013
spinal and bulbar muscular atrophy	drug	Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy	Shih, Charles C-Y	Androscience Corporation	2014
stroke	protein	Development of Annexin A2 Plus TPA as a Novel Stroke Thromolytic Therapy	Wang, Xiaoying	Massachusetts General Hospital	2016
muscular dystrophy	protein	Development of Biglycan As a Therapeutic for Duchenne Muscular Dystrophy	Fallon, Justin	Brown University	2013
neuropathic pain	drug	Development of Estrogen Receptor B Selective Receptor Agonists to Treat Neuropath	Burstein, Ethan S.	Acadia Pharmaceuticals, Inc.	2015
muscular dystrophy	drug	Development of Novel Small Molecules for Delaying the Progression of Muscular Dys	Sweeney, Hugh Lee	University of Pennsylvania	2012
stroke	drug	Development of Toll-Like Receptor Agonists as Neuroprotectants in Brain Ischemia	Stenzel-Poore, Mary	Oregon Health and Science University	2014
lysosomal storage disorder	gene therapy	Gene Therapy for Metachromatic Leukodystrophy	Crystal, Ronald G.	Weill Medical College of Cornell University	2014
ALS	cell therapy	Glial Progenitor Cells for Treatment of ALS	Maragakis, Nicholas	Johns Hopkins Univesity	2014
glioma	gene therapy	Gutless Adenovirus Mediated Gene Therapy for Glioma	Castro, Maria	University of Michigan School of Medicine	2012
lysosomal storage disorder	fusion protein	Iduronidase Replacement Therapy of the Brain in Hurler's Syndrome	Boado, Ruben	Armagen Technologies, Inc.	2012
amputations	device	Implantable Myoelectric Recording Array for Control of Prostheses	McDonnall, Daniel	Ripple, LLC	2016
epilepsy	device	Low-Frequency Sine-Wave Neurostimulation Therapy for Epilepsy	Goodman, Jeffrey	Suny Downstate Medical Center	2014
spinal cord injury	device	Multi-Functional Neuroprosthetic Systems for Restoration of Motor Function	Peckham, P Hunter	Case Western Reserve University	2013
glioma	viral therapy	Neural Stem Cell Based Virotherapy for Malignant Glioma	Lesniak, Maciej	University of Chicago	2015
muscular dystrophy	peptide	NF-Kappabeta Therapy for Duchenne Muscular Dystrophy	Guttridge, Denis	Ohio State University	2013
Huntington's	drug	Novel Histone Deacetylase Inhibitors as Therapeutic for Huntington's Disease	Gottesfeld, Joel	Scripps Research Institute	2014
neuropathy	gene therapy	NT-3 Gene Therapy to Improve Peripheral Nerve Function Induced by Genetic Defect	Sahenk, Zarife	Research Inst Nationwide Children's Hosp	2013
stroke	drug	Phenylpropanoid Analogs to Treat Stroke	Lapchak, Paul	Cedars-Sinai Medical Center	2015
traumatic brain injury	protein	Polynitroxylated Pegylated Hemoglobin for Traumatic Brain Injury Resuscitation	Hsia, Carleton	Synzyme Technology, Inc.	2016
traumatic brain injury	drug	Preclinical Cyclosporin A Therapy Trials for Pediatric TBI	Margules, Susan S.; Duhaime, Ann-Christine	University of Pennsylvania	2016
subarachnoid hemmorhage	drug	Preclinical Development of a Context-Dependent NMADR Neuroprotectant for Treatment	Koszalka, George W.; Myers, Scott J.	Neurop, Inc.	2015
Parkinson's	drug	Preclinical Development of JNK3 Inhibitors to Treat Parkinson's Disease	Lograsso, Phillip	Scripps Research Institute	2013
Alzheimer's	drug	Preclinical Development of NGP 555 for the Prevention of AD	Comer, William T.	Neurogentic Pharmaceuticals, Inc.	2015
neuropathy	gene thrapy	Preclinical Development of NT3-Expressing HSV Vector	Fink, David J.	University of Michigan	2014
neurofibroma	drug	Preclinical Testing of Targeted Therapies for Neurofibromas	Clapp, David W	Indiana Univ-Purdue Univ at Indianapolis	2012
glioma	viral therapy	Preclinical Toxicity Evaluation of a Potent Oncolytic Virus	Chiocca, E. Antonio	Ohio State University	2013
stroke	drug	Progesterone in the Treatment of Ischemic Stroke	Stein, Donald G.	Emory University	2013
stroke	antibody	Reducing Stroke by a Novel, Clot-Dissolving Antibody	Kussie, Paul H.; Reed, Guy L.	Translational Sciences, Inc.	2015
spinal muscular atrophy	drug	Tetracycline Derivatives as SMN2 MRNA Splicing Modifiers for Treatment of SMA	Tanaka, S. Ken	Paratek Pharmaceuticals	2014
Huntington's	drug	Therapeutic Candidates for Huntington's Disease: From Lead to Ind	Kazantsev, Aleksey	Massachusetts General Hospital	2015
stroke	device	Transcranial Laser Therapy of Ischemic Stroke	Zivin, Justin A.	University of California, San Diego	2015
Down Syndrome	drug	Translating Innovative Research Discoveries to Potential Therapeutic for Down Syndrome	Messersmith, Elizabeth K.	Balance Therapeutics, Inc.	2014
glioma	gene therapy	Translational Development of Replication-Competent Retrovirus Vectors	Kasahara, Noriyuki	University of California Los Angeles	2014
lysosomal storage disorder	gene therapy	Treating the CNS and Somatic Diseases of MPS IIB Systemic Gene Delivery	Fu, Haiyan; Flanigan, Kevin M.	Research Institute at Nationwide Children's Hospital	2015
neuropathy, pain	device	Wireless Neurostimulation for the Relief of Chronic Neuropathic and Inflammatory	Armstrong, Scott	Microtransponder, Inc.	2013
neuropathic pain	gene therapy	XT-101: A Novel and Potent Non-Opioid Treatment for Neuropathic Pain	Chavez, Raymond	Xalud Therapeutics, Inc.	2015

Last updated March 20, 2013