Neurodegeneration

The Neurodegeneration cluster portfolio consists of research on adult onset neurodegenerative diseases of all types, broadly focusing on pathogenesis, treatment and prevention. Research on the normal structure and function of neural systems is also included to enable identification of intervention strategies. The role of the programmatic team is to develop, implement and manage these research programs and to promote the translation of research findings into clinical practice.  Included in the portfolio are topics such as neuronal cell death, protein misfolding, aggregation, and  processing, mitochondrial pathologies, epidemiological studies, genetic studies including genome-wide association studies (GWAS), biomarker studies, clinical studies including deep brain stimulation and gene therapy and translational projects that will accelerate bench-to-bedside therapies for neurodegenerative disorders.

Quick Links

• Parkinson's Disease Research
  
• NINDS Parkinson's Disease Biomarker Program (PDBP)
•  CINAPS - Standardized Animal Model Neuroprotective Compound Screening for Parkinson's Disease
• Information for Ancillary Studies in PREDICT-HD
• Alzheimer's Disease-Related Dementias Workshop
• Huntington's Disease Research (coming soon)
  

Workshop Summary

• Clinical Development in FTD Workshop (June 3-4, 2012)
• 3rd Induced Pluripotent Stem Cells Consortia Workshop (March 29-30, 2012)
• NINDS Parkinson's Disease Biomarkers Program Scientific Liaison Group Meeting (December 15, 2011)
• 13^th Annual Udall Centers Directors' Meeting (September 13-14, 2011)
• Genetics of Neurodegenerative Disease--Neurochip and Beyond (April 20-21, 2011)
• 2^nd Induced Pluripotent Stem Cells Consortia Workshop (December 15, 2010)
• Advances in Disease Modeling for ALS and FTD (November 12, 2010)
• NINDS Neurodegeneration Cluster Workshop Schedule
• All NINDS Workshop Summaries and Conference Proceedings

Neurodegeneration Funding Initiatives and Requests for Information

• Ancillary Studies in PREDICT-HD (U01) PAR-12-097  Contact: Margaret Sutherland, Ph.D. expiration date April 12, 2014
•  NINDS Human Genetics Resource Center/NINDS Repository Goals, Access, and Use Contact Roderick Corriveau, Ph.D.
• Validation of Novel Therapeutic Targets for Huntington’s Disease Contact: Margaret Sutherland, Ph.D. expiration date May 8, 2013
• All active Neurodegeneration Funding Initiatives

Neurodegeneration Program Staff

Scientific Staff	Research Area
Roderick Corriveau, Ph.D. Program Director Point of contact: AD, vascular dementias, hereditary spastic paraplegia	Alzheimer’s disease, vascular dementias, and hereditary spastic paraplesia. For Alzheimer’s disease research, studies focused on molecular mechanisms of disease pathophysiology with areas of emphasis including but not limited to: (1) APP, beta-amyloid, presenilins, tau, neurotrophins and synaptic proteins; (2) animal models; (3) neuroinflammation; (4) post-translational protein modifications; (5) protein trafficking and clearance.
Amelie Gubitz, Ph.D. Program Director Point of contact: ALS, SBMA (Kennedy's Disease)	Basic, translational, and clinical research studies of amyotrophic lateral sclerosis (ALS) and X-linked spinal and bulbar muscular atrophy (SBMA, Kennedy's Disease).
Beth-Anne Sieber, Ph.D. Program Director Point of contact: PD, parkinsonism, ET, dystonia	Parkinson’s disease (PD), including molecular biology, cell biology, neurochemistry, deep brain stimulation (DBS), gene therapy, motor and non-motor manifestations. Parkinsonian disorders including multiple system atrophy (MSA) and progressive supranuclear palsy (PSP); essential tremor; dystonia.
Margaret Sutherland, Ph.D. Program Director Point of contact: HD, FTD	Huntington’s Disease (HD), Frontotemporal dementia (FTD), Parkinson’s Disease (PD), genome-wide association (GWA) studies, genetics, biomarkers, stem cells, protein and mitochondrial dynamics, translational research, clinical trials
Andrey Kuzmichev Ph.D. Health Program Specialist
Pamela Wernett, Ph.D. Health Program Specialist

Address

Neuroscience Center
6001 Executive Blvd.
Bethesda, Maryland 20892