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Dementia of Alzheimer's Disease and Epilepsy - Converging Mechanisms (NIH Workshop)

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Hilton Washington DC/Rockville Executive Meeting Center
Rockville, Maryland
October 15–17 2008

Workshop Summary

Agenda


Wednesday, October 15, 2008
5:00–6:00 p.m.     Registration
6:00–10:00 p.m.     Dinner and Opening Session
       
Plenary Introduction
7:30–8:15 p.m.     Pathogenic Mechanisms of Alzheimer’s Dementia
Lennart Mucke
8:15–9:00 p.m.     Mechanisms Linking Alzheimer’s Dementia and Epilepsy
Jeff Noebels
9:00–10:00 p.m.     General Discussion
       
Thursday, October 16, 2008
7:30–8:30 a.m.     Registration and Continental Breakfast
8:30–8:45 a.m.     Short Introduction-Charge to Participants
       
Session 1: Alzheimer’s Disease (AD) and Epilepsy? Clinical Dilemma
Chair: Lennart Mucke
Suggested Topics (10-minute talks followed by 10-minute discussions)
8:45–9:05 a.m.     A Review of Co-Morbidities of AD and Epilepsy
Allen Hauser and Nick Scarmeas
9:05–9:25 a.m.     Cognitive Impairment in AD and Epilepsy
Bruce Hermann
9:25–9:45 a.m.     Detection of Nonconvulsive Seizure Activity
Andy Cole
9:45–10:05 a.m.     fMRI for the Measurement of Mesial Temporal Activity
Jean Gotman
10:05–10: 30 a.m.     Coffee Break
10:30–10:50 a.m.     Neuronal Network Dysfunction in AD Brain
Bradford Dickerson
10:50–11:20 a.m.     Discussion
       
Session 2: Clinical Trial Design
Chairs: Marc Dichter and Jacqueline French
11:20–11:40 a.m.     Designing a Clinical Trial for Antiepileptic Drugs in Dementia I
Jacqueline French
11:40–12:00 a.m.     Designing a Clinical Trial for Antiepileptic Drugs in Dementia II
Steven DeKosky
12:00–12:30 p.m.     Working Lunch
       
Session 3: Shared Mechanisms
Chair: Helen Scharfman
1:30–1:50 p.m.     Neuronal Dysfunction and Remodeling in Alzheimer’s Models
Jorge Palop
1:50–2:10 p.m.     Neuronal Dysfunction and Remodeling in Epilepsy Models
Asla Pitkaanen
2:10–2:30 p.m.     Pharmacology of Epilepsy and Dementia:A Synaptic Perspective
Ray Dingledine
2:30–3:00 p.m.     Pharmacologies of Theraputics for AD and Epilepsy
Jim Cloyd
3:00–3:20 p.m.     Coffee Break
3:20–3:50 p.m.     Discussion
       
Session 4: Genetic Models
Chair: Jeff Noebels
4:00–4:20 p.m.     Genes and Mechanisms of AD
Gerard Schellenberg
4:20–4:40 p.m.     Genes and Mechanisms of Epilepsy
Thomas Sutula
4:40–5:10 p.m.     Discussion
6:00 p.m.     Dinner
       
Friday, October 17, 2008
7:30–8:30 a.m.     Continental Breakfast
       
Session 5: Specific Recommendations for Moving Forward
8:30–9:00 a.m.     The Clinical Perspective
Jacqueline French and Steve DeKosky
9:00–9:45 a.m.     General Discussion
9:45–10:00 a.m.     Coffee Break
10:00–10:30 a.m.     The Basic Neuroscience Perspective
Lennart Mucke and Jeff Noebels
10:30–11:30 a.m.     General Discussion
11:30–12:00 p.m.     General Discussion and Wrap-Up
12:00 p.m.     Adjourn

 

Participant List

Matthew P. Anderson, M.D., Ph.D.

Beth Israel Deaconess/Harvard Medical School

Seetha Bhagavan, Ph.D.

CSR/NIH

Debbie Carr

Epilepsy Foundation

Tracy Chen, Ph.D., DABT

NINDS/NIH

James Cloyd, Pharm.D.

University of Minnesota

Andrew Cole, M.D., FRCP(C)

Harvard Medical School

Steve Dekosky, M.D.

University of Virginia School of Medicine

Marc A. Dichter, M.D., Ph.D.

University of Pennsylvania

Bradford C. Dickerson, M.D.

Harvard Medical School

Ray Dingledine, Ph.D.

Emory University School of Medicine

Cerise Elliott, Ph.D.

NIA/NIH

Rene Etcheberrigaray, M.D.

CSR/NIH

Jacqueline French, M.D.

New York University School of Medicine

Brandy Fureman, Ph.D.

NINDS/NIH

Michela Gallagher, Ph.D.

Johns Hopkins University

Alison Goate, D.Phil.

Washington University School of Medicine

Jean Gotman, Ph.D.

McGill University

Gunnar Gouras, M.D.

Weill Cornell Medical College

Allen Hauser, M.D.

Columbia University

Bruce Hermann, Ph.D.

University of Wisconsin School of Medicine and Public Health

Margaret Jacobs

NINDS/NIH

Joanna Jankowsky, Ph.D.

Baylor College of Medicine

Kevin M. Kelly, M.D, Ph.D.

Drexel University College of Medicine

Melinda Kelley, Ph.D.

NINDS/NIH

Ti Lin, Ph.D.

NINDS/NIH

Carrie McDonald, Ph.D.

University of California, San Diego

Guy McKhann, M.D.

Johns Hopkins University

Istvan Mody, Ph.D.

UCLA School of Medicine

John C. Morris, M.D.

Washington University in St. Louis

Marcelle Morrison-Bogorad, Ph.D.

NIA/NIH

Lennart Mucke, M.D.

University of California, San Francisco

Suzan Nadi, Ph.D.

CSR/NIH

Dan Nicholson, Ph.D.

Northwestern University Feinberg
School of Medicine

Jeffrey L. Noebels, M.D., Ph.D.

Baylor College of Medicine

Jorge J. Palop, Ph.D.

University of California, San Francisco

Manisha Patel, Ph.D.

University of Colorado Denver

Suzana Petanceska, Ph.D.

NIA/NIH

Creighton H. Phelps, Ph.D.

NIA/NIH

Joann Pierce

Epilepsy Foundation

Asla Pitkänen, M.D., Ph.D.

University of Kuopio

Larry Refolo, Ph.D.

NINDS/NIH

Erik Roberson, M.D., Ph.D.

University of Alabama at Birmingham

Lynn Rundhaugen, M.P.H.

NINDS/NIH

Laurie Ryan, Ph.D.

NIA/NIH

Nikos Scarmeas, M.D., M.Sc.

Columbia University Medical Center

Helen Scharfman, Ph.D.

New York University

Gerard D. Schellenberg, Ph.D.

University of Pennsylvania Medical School

Catherine Schevon, M.D., Ph.D.

Columbia University

Liz Schreiber

Epilepsy Foundation

Nina Silverberg, Ph.D.

NIA/NIH

D. Stephen Snyder, Ph.D.

NIA/NIH

James P. Stables, M.S. Admin.

NINDS/NIH

John Stern, M.D.

UCLA School of Medicine

Margaret Sutherland, Ph.D.

NINDS/NIH

Thomas P. Sutula, M.D., Ph.D.

University of Wisconsin

Christina Vert, M.S.

NINDS/NIH

Molly V. Wagster, Ph.D.

NIA/NIH

Karen Wilcox, Ph.D.

University of Utah

Bradford Wise, Ph.D.

NIA/NIH

  
   

 

Last updated March 02, 2009