Request for Information: Whole Genome Sequencing, Data Analysis, Storage and Annotation

This is a time sensitive Request for Information (RFI) issued by the National Institute of Neurological Disorders and Stroke (NINDS). The purpose of the RFI is to solicit information on the research needs of the NINDS community for whole genome sequencing services and accompanying data storage, analysis and annotation services. The responses to the RFI will be collected and evaluated by Institute staff to assess how best to meet the current and future needs for whole genome sequencing as it relates to neurologic disease.

Sequencing Services

1. Describe the whole genome sequencing services available or planned at your institution.
2. Describe the composition of your research cohort (e.g. small or large families, population based) which will utilize whole genome sequencing.
3. Indicate how you anticipate whole genome sequencing will contribute to your field of research.
4. Provide your rationale for choosing whole genome sequencing over whole exome sequencing?
5. If you plan to utilize whole genome sequencing how many samples would you sequence within the next 12 months? How will these samples be chosen?.
6. Outline the plans of your laboratory or institution regarding storage capacity for raw data generated from whole genome sequencing.
7. What are the plans of your laboratory or institution regarding analytical support for sequence assembly, variant identification and annotation?
8. Provide your perspective on the constraints regarding the public sharing of genomic sequences and associated phenotype for your research cohort.

General Information

1. Please identify the nature of your interest in the area of whole genome sequencing services (i.e. are you a biomedical or clinical researcher, a member of an advocacy or community group, or other?).
2. If you are a member of a particular advocacy or professional organization, please indicate the name of the organization.
3. Please indicate your main area of research interest.
4. Your name:
5. You email address:

Responses must be submitted electronically using this web form, and will be accepted through May 30, 2011. Replies to individual questions are optional, and the site will permit anonymous responses. The information provided will be analyzed and may appear in various reports.

Please direct all inquiries to:

Margaret Sutherland, PhD
Program Director, Neurodegeneration Cluster
NINDS / NIH
NSC Rm 2203
6001 Executive Blv.
Bethesda, MD 20892
Phone (301) 496-5680
Fax (301) 480-1080
E-mail: sutherlandm@ninds.nih.gov

Last updated July 20, 2011