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NINDS Request for Information on Stroke Research Priorities


THE DEADLINE FOR RESPONDING TO THIS RFI WAS JULY 8, 2012. SUBMISSIONS ARE NO LONGER BEING ACCEPTED ON THIS WEBSITE.

Information Requested

NOT-NS-12-009 invites input on priorities for the stroke research community to address over the next 5-10 years. The priorities should represent cross-cutting research opportunities that have a high probability of leading to a major advance in our biologic understanding or treatment of the disease.

Identify and provide your input on up to three high priority stroke research efforts that if completed over the next 5-10 years would lead to major advances in stroke science. We are interested in basic, translational, and/or clinical research areas as well as approaches that cut across these areas. Please note that you do not need to be a stroke specialist to respond and we welcome input from related disciplines.

Your input will be used by the planning panel during their consideration of the research priorities. For each topic submitted, please comment on these five elements:

  1. Description – The challenge, opportunity or research question for the stroke field to address, and indicate its relevance to one or more of the following three areas: prevention, acute treatment, or recovery and rehabilitation.
  2. Rationale – The background or scientific evidence that forms the basis for this research topic/question.
  3. Readiness – Whether the opportunity or challenge is primed for action now and what the expected deliverables would be after a 5-10 year effort (considering strategic advantages of the current state of the science, infrastructure capacity, new technologies, new discovery, etc.), or if this is a newer area of science that needs to be further developed now because of its great potential for high scientific payoff in the future (i.e. high risk / high reward, but longer time frame).
  4. Impact - The immediate and long-term impacts that accomplishment in this area or answering this stroke research question would have on the science and on public health. This can include justifying why this is a national stroke research priority.
  5. Approach - Potential approach or study design to pursue the scientific opportunity (team science, centers of excellence, science challenge, prospective randomized trial, epidemiologic study, prospective data collection without randomization, etc.). Include who in the research community would need to become engaged, and whether existing infrastructure or research capacity is sufficient or would need to be developed. Also indicate any barriers that need to be overcome to allow this area to move forward and suggest strategies for addressing them.

* :  

* : (Click for details).

The challenge, opportunity or research question for the stroke field to address, and indicate its relevance to one or more of the following three areas: prevention, acute treatment, or recovery and rehabilitation.




* : (Click for details).

The background or scientific evidence that forms the basis for this research topic/question.




* : (Click for details).

Whether the opportunity or challenge is primed for action now and what the expected deliverables would be after a 5-10 year effort (considering strategic advantages of the current state of the science, infrastructure capacity, new technologies, new discovery, etc.), or if this is a newer area of science that needs to be further developed now because of its great potential for high scientific payoff in the future (i.e. high risk / high reward, but longer time frame).




* : (Click for details).

The immediate and long-term impacts that accomplishment in this area or answering this stroke research question would have on the science and on public health. This can include justifying why this is a national stroke research priority.




* : (Click for details).

Potential approach or study design to pursue the scientific opportunity (team science, centers of excellence, science challenge, prospective randomized trial, epidemiologic study, prospective data collection without randomization, etc.). Include who in the research community would need to become engaged, and whether existing infrastructure or research capacity is sufficient or would need to be developed. Also indicate any barriers that need to be overcome to allow this area to move forward and suggest strategies for addressing them.


Plus Sign   Add a second topic area (optional)

*   

* : (Click for details).

The challenge, opportunity or research question for the stroke field to address, and indicate its relevance to one or more of the following three areas: prevention, acute treatment, or recovery and rehabilitation.


* : (Click for details).

The background or scientific evidence that forms the basis for this research topic/question.


* : (Click for details).

Whether the opportunity or challenge is primed for action now and what the expected deliverables would be after a 5-10 year effort (considering strategic advantages of the current state of the science, infrastructure capacity, new technologies, new discovery, etc.), or if this is a newer area of science that needs to be further developed now because of its great potential for high scientific payoff in the future (i.e. high risk / high reward, but longer time frame).



* : (Click for details).

The immediate and long-term impacts that accomplishment in this area or answering this stroke research question would have on the science and on public health. This can include justifying why this is a national stroke research priority.



* : (Click for details).

Potential approach or study design to pursue the scientific opportunity (team science, centers of excellence, science challenge, prospective randomized trial, epidemiologic study, prospective data collection without randomization, etc.). Include who in the research community would need to become engaged, and whether existing infrastructure or research capacity is sufficient or would need to be developed. Also indicate any barriers that need to be overcome to allow this area to move forward and suggest strategies for addressing them.



Plus Sign   Add a third topic area (optional)

*   

* : (Click for details).

The challenge, opportunity or research question for the stroke field to address, and indicate its relevance to one or more of the following three areas: prevention, acute treatment, or recovery and rehabilitation.


The background or scientific evidence that forms the basis for this research topic/question.


* : (Click for details).

Whether the opportunity or challenge is primed for action now and what the expected deliverables would be after a 5-10 year effort (considering strategic advantages of the current state of the science, infrastructure capacity, new technologies, new discovery, etc.), or if this is a newer area of science that needs to be further developed now because of its great potential for high scientific payoff in the future (i.e. high risk / high reward, but longer time frame).



* : (Click for details).

The immediate and long-term impacts that accomplishment in this area or answering this stroke research question would have on the science and on public health. This can include justifying why this is a national stroke research priority.



* : (Click for details).

Potential approach or study design to pursue the scientific opportunity (team science, centers of excellence, science challenge, prospective randomized trial, epidemiologic study, prospective data collection without randomization, etc.). Include who in the research community would need to become engaged, and whether existing infrastructure or research capacity is sufficient or would need to be developed. Also indicate any barriers that need to be overcome to allow this area to move forward and suggest strategies for addressing them.






General Information

Note: All of the following fields are optional. Proprietary, classified, confidential, or sensitive information should not be included in your response.



  1. Please provide your name and email address.

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Responses

To assure consideration, your responses must be received by July 8, 2012. Responses to this RFI must be submitted electronically using the web-based format at: www.ninds.nih.gov/strokerfi

Responses to this RFI are voluntary. The comments collected will be analyzed and considered in planning and development of future initiatives. Any personal identifiers will be removed when responses are compiled. Proprietary, classified, confidential, or sensitive information should not be included in your response. This Request for Information (RFI) is for planning purposes only and is not a solicitation for applications or an obligation on the part of the United States (U.S.) Government to provide support for any ideas identified in response to it. Please note that the U.S. Government will not pay for the preparation of any comment submitted or for its use of that comment.

Inquiries

Please direct specific questions about this RFI to:

Katie Pahigiannis, Ph.D.
NINDS Office of Science Policy and Planning
National Institutes of Health
Phone: 301-496-9271
Email: katie.pahigiannis@nih.gov

(*) Denotes Required Fields

Last updated July 31, 2013