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Tremor Press Releases

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NIH awards $35 Million for Centers for Collaborative Research in Fragile X
Tuesday, Sep 23, 2014
The National Institutes of Health is making funding awards of $35 million over the next five years to support the Centers for Collaborative Research in Fragile X program. Investigators at these centers will seek to better understand Fragile X-associated disorders and work toward developing effective treatments.

U.S. Army soldier in Afghanistan

First cases of degenerative brain disease CTE found in veterans with blast injuries
Friday, Jun 29, 2012
Some veterans who experience blast-related head injuries can develop the same kind of long-term brain damage seen in athletes who have had multiple head injuries on the playing field. The finding expands the potential public health impact of chronic traumatic encephalopathy (CTE) – the name for degenerative changes in the brain that sometimes occur after a history of multiple concussions.

Individuals performing tai chi

Tai chi helps Parkinson’s patients with balance and fall prevention
Thursday, May 10, 2012
For Parkinson’s disease, exercise routines are often recommended to help maintain stability and the coordinated movements necessary for everyday living. An NIH-funded study evaluated three different forms of exercise – resistance training, stretching, and tai chi – and found that tai chi led to the greatest overall improvements in balance and stability for patients with mild to moderate Parkinson’s disease.

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NIH-funded twin study finds occupational chemical exposure may be linked to Parkinson’s risk
Monday, Nov 14, 2011
New research in twins contributes to the increasing evidence that repeated occupational exposure to certain chemical solvents raises the risk for Parkinson’s disease. Of the six chemicals investigated, researchers concluded that two common chemical solvents, trichloroethylene (TCE) and perchloroethylene (PERC), are significantly linked to development of this disease.

Movement disorders can add difficulty to simple tasks, such as pouring water from one cup into another, as shown here.

YouTube videos can inaccurately depict Parkinson’s disease and other movement disorders
Wednesday, Sep 21, 2011
After reviewing the most frequently watched YouTube videos about movement disorders, a group of neurologists found that the people in the videos often do not have a movement disorder. As described in a Letter to the Editor in this week’s New England Journal of Medicine, such medical misinformation may confuse patients seeking health information and advice online.

An illustration of DBS for Parkinson's disease.  Fine wires are implanted in the brain and stimulation is controlled by a pacemaker-like device under the skin, usually near the shoulder blade.

Deep Brain Stimulation at Two Different Targets Produces Similar Motor Benefits for Parkinson’s Patients
Wednesday, Jun 2, 2010
In a major study, investigators have compared how individuals with Parkinson’s disease respond to deep brain stimulation (DBS) at two different sites in the brain. Contrary to current belief, patients who received DBS at either site in the brain experienced comparable benefits for the motor symptoms of Parkinson’s.

In Parkinson's Disease, the Brain Stops Playing by the 'Rules'
Tuesday, Feb 24, 2009
Parkinson's disease (PD) slowly robs people of their ability to control movement. Purposeful movements become slow and rigid, while periods of rest become interrupted by shakes and tremors. In a study reported in Science, researchers say they are closer to understanding how these symptoms arise, and possibly how to treat them.

Deep Brain Stimulation More Effective than Best Medical Therapy Even in Older Parkinson’s Patients
Wednesday, Jan 7, 2009
Deep brain stimulation (DBS) was more effective than best medical therapy (BMT) in improving “on” time-- periods of unimpeded motor function--and quality of life in a large comparison study of more than 200 advanced Parkinson’s disease (PD) patients. Patients in the DBS group, even those over 70 years old, gained as much as four and a half hours of on time compared to the BMT group, who gained none.

Study Identifies Possible Trigger for Parkinson's Disease
Monday, Feb 25, 2008
A chemical interaction that blocks cells' ability to break down damaged proteins may trigger development of Parkinson's disease (PD), a new study shows. Finding ways to overcome the blockage could lead to strategies for preventing the disease or stopping its progression.

Blood Pressure Drug May Slow Parkinson's Disease
Friday, Aug 3, 2007
For decades, scientists have tried to learn what causes the death of a select group of nerve cells in the brains of people with Parkinson's disease (PD). New research identifies an unusual mode of activity in these cells that makes them exceptionally vulnerable to toxins and stress and shows that a common drug can protect these neurons in animal models of PD. This work suggests a possible new way to slow or prevent the disease.

NIH Announces Phase III Clinical Trial of Creatine for Parkinson's Disease
Thursday, Mar 22, 2007
The NIH National Institute of Neurological Disorders and Stroke (NINDS) is launching a large-scale clinical trial to learn if the nutritional supplement creatine can slow the progression of Parkinson's disease (PD). While creatine is not an approved therapy for PD or any other condition, it is widely thought to improve exercise performance. The potential benefit of creatine for PD was identified by Parkinson’s researchers through a new rapid method for screening potential compounds.

Stem Cells Make Neurons, and Tumors, in Rat Model of Parkinson's Disease
Thursday, Mar 1, 2007
In a new study that illustrates the promise and perils of stem cell therapy, scientists found that implanting human embryonic stem cells led to dramatic functional improvement – but also to brain tumors – in a rat model of Parkinson’s disease (PD).

Dopamine Drug Leads to New Neurons and Recovery of Function in Rat Model of Parkinson's Disease
Tuesday, Jul 4, 2006
In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases.

Preliminary Results Shows Creatine and Minocycline May Warrant Further Study in Parkinson’s Disease
Thursday, Feb 23, 2006
A National Institutes of Health-sponsored clinical trial with 200 Parkinson's disease patients has shown that creatine and minocycline may warrant further consideration for study in a large trial.

Advancements in Symptomatic and Neuroprotective Treatments Highlighted at First World Parkinson Congress
Thursday, Feb 23, 2006
At today’s World Parkinson Congress, the first international gathering of Parkinson’s researchers, health professionals, patients, and caregivers, some of the world’s leading neuroscientists from the United States, Canada, and Sweden presented on innovative therapies that show promise in controlling the symptoms of Parkinson’s, restoring lost function, and even altering the progression of the disease.

Living with Parkinson’s: A Jekyll and Hyde Existence
Thursday, Feb 23, 2006
"I live a strange double life," said 37-year-old Tom Isaacs, who was diagnosed with Parkinson's disease (PD) ten years ago and is a co-founder of the Cure Parkinson's Trust in the United Kingdom. "I am both Dr. Jekyll and Mr. Hyde."

Internationally Acclaimed Pianist Gives Thanks to the National Institutes of Health for Innovative Treatment That Enabled His Comeback
Friday, Nov 12, 2004
Maestro Leon Fleisher, one of the world's most renowned classical pianists and three-time Grammy-nominee, will perform selections from his critically acclaimed new CD "Two Hands" at a pre-Thanksgiving event at the National Institutes of Health (NIH). More than 40 years ago, at the height of his career, Mr. Fleisher lost the use of his right hand to dystonia, the third most common neurological movement disorder after Parkinson's disease and essential tremor. He could no longer play the piano with both hands and the frequently misdiagnosed disorder severely impeded his performance of everyday tasks. About 10 years ago, physicians at the NIH were able to diagnose the problem as a focal dystonia and start him on a therapy which helped to reverse the condition.

Gene for Rapid-Onset Dystonia Parkinsonism Found
Thursday, Sep 23, 2004
Investigators funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the gene responsible for a rare form of dystonia known as rapid-onset dystonia parkinsonism (RDP).
Fact Sheet

Major New Finding on Genetics of Parkinson's Disease Zeroes In on Activity of Alpha Synuclein
Thursday, Oct 30, 2003
Scientists investigating a rare familial form of early-onset Parkinson's disease have discovered that too much of a normal form of the alpha-synuclein gene may cause Parkinson's disease. The finding, reported in the October 31, 2003, issue of Science, shows that abnormal multiplication of the alpha-synuclein gene can cause the disease.
Fact Sheet

Investigators Explore Selective Silencing of Disease Genes
Wednesday, Oct 15, 2003
A new strategy to shut down mutant gene expression in the brain may someday be useful to treat a wide range of hereditary neurodegenerative diseases, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases.
Fact Sheet

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease
Monday, Oct 14, 2002
Results of the first placebo-controlled, multicenter clinical trial of the compound coenzyme Q10 suggest that it can slow disease progression in patients with early-stage Parkinson's disease (PD). While the results must be confirmed in a larger study, they provide hope that this compound may ultimately provide a new way of treating PD.
Fact Sheet

Scientists Identify Potential New Treatment for Huntington's Disease
Wednesday, Feb 27, 2002
A drug called cystamine alleviates tremors and prolongs life in mice with the gene mutation for Huntington's disease (HD), a new study shows. The drug appears to work by increasing the activity of proteins that protect nerve cells, or neurons, from degeneration. The study suggests that a similar treatment may one day be useful in humans with HD and related disorders.
Fact Sheet

NINDS to Support Eight New Parkinson's Disease Research Centers of Excellence
Tuesday, Sep 28, 1999
As part of its efforts to defeat Parkinson's disease, the National Institute of Neurological Disorders and Stroke (NINDS) today announced plans to award new grants to eight top universities. The new awards will raise to eleven the number of Parkinson's Disease Research Centers of Excellence the Institute funds and represent a total commitment of $49 million to be spent over the next 5 years. Added to the $24 million committed to three such centers in September of 1998, this brings total Institute funding for the Parkinson's Disease Research Centers of Excellence program to $73 million.

Transplanted Neural Stem Cells Migrate Throughout the Abnormal Brain, Reduce Disease Symptoms
Monday, Jun 7, 1999
For years, researchers have probed the mysteries of neural stem cells -- immature cells that can differentiate into all the cell types that make up the brain -- with the idea that they might be useful for treating brain disorders such as Parkinson's disease. Important new animal research now suggests that these cells may be effective in treating a much broader array of brain diseases than previously anticipated, including Alzheimer's disease and many childhood brain disorders.

Genetics Not Significant to Developing Typical Parkinson's Disease
Tuesday, Jan 26, 1999
Genetic factors do not play a significant role in causing the most common form of Parkinson's disease (PD), according to a study to be published in the January 27, 1999 issue of the Journal of the American Medical Association. This epidemiological study, the largest of its kind to investigate the role of genetic or environmental causes of PD, examined 19,842 white male twins enrolled in a large registry of World War II veteran twins.

NINDS Awards Almost $24 Million to Support Parkinson's Disease Research Centers of Excellence
Friday, Dec 4, 1998
Three top university hospitals will receive a total of almost $24 million from the National Institute of Neurological Disorders and Stroke (NINDS) to advance understanding of Parkinson's disease and related movement disorders. Investigators at Emory University, Massachusetts General Hospital, and The Johns Hopkins University School of Medicine will spend the next five years unraveling the cause or causes of Parkinson's disease and seeking new ways to diagnose and treat it. They will also provide state-of-the-art, multidisciplinary training for young scientists preparing for research careers investigating Parkinson's disease and related neurodegenerative disorders.

Gene Locus Found for Essential Tremor Disorder
Friday, Nov 7, 1997
Researchers from the National Institute of Neurological Disorders and Stroke have located a gene locus responsible for the most common human movement disorder, essential tremor (ET). In an article in the November 1997 issue of Movement Disorders, Joseph J. Higgins, M.D., Lana T. Pho, and Linda E. Nee, M.S.W., report how they traced the gene to the short arm of chromosome 2.

Gene Sequenced for Disabling Childhood Movement Disorder: Early-Onset Torsion Dystonia Protein Found
Wednesday, Sep 3, 1997
Scientists have sequenced the gene responsible for early-onset torsion dystonia and have found a new class of proteins that may provide insight into all of the dystonia disorders. The discovery of the gene will make diagnosis of early-onset torsion dystonia easier and allow scientists to investigate other factors that might contribute to the disease.

Scientists Locate Parkinson's Gene
Thursday, Nov 14, 1996
For the first time, scientists have pinpointed the location of a gene they believe is responsible for some cases of Parkinson's disease. Their discovery provides strong evidence that a genetic alteration is capable of causing the disease. The study, published in the November 15 issue of Science,1 sheds light on the mysterious origins of this devastating neurological disease that affects about 500,000 Americans.