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NINDS Transverse Myelitis Information Page

Condensed from Transverse Myelitis Fact Sheet

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What is Transverse Myelitis?

Transverse myelitis is a neurological disorder caused by inflammation across both sides of one level, or segment, of the spinal cord. The segment of the spinal cord at which the damage occurs determines which parts of the body are affected.  Damage at one segment will affect function at that segment and segments below it. In people with transverse myelitis, inflammation usually occurs at the thoracic (upper back) level, causing problems with leg movement and bowel and bladder control, which require signals from the lower segments of the spinal cord.   What usually begins as a sudden onset of lower back pain, muscle weakness, or abnormal sensations in the toes and feet can rapidly progress to more severe symptoms, including paralysis, urinary retention, and loss of bowel control.

Is there any treatment?

No effective cure currently exists for people with transverse myelitis.  Physicians often prescribe corticosteroid therapy during the first few weeks of illness to decrease inflammation.  Following initial therapy, the most critical part of the treatment for this disorder consists of keeping the patient’s body functioning while hoping for either complete or partial spontaneous recovery of the nervous system.  If an individual begins to recover limb control, physical therapy begins to help improve muscle strength, coordination, and range of motion.

What is the prognosis?

Most individuals will have only one episode of transverse myelitis.  Recovery usually begins within 2 to 12 weeks of the onset of symptoms and may continue for up to 2 years and in some cases longer--requiring aggressive physical therapy and rehabilitation. However, if there is no improvement within the first 3 to 6 months, complete recovery is unlikely (although some recovery can occur). Historic data, shows that about one-third of people affected with transverse myelitis experience good or full recovery from their symptoms.  Another one-third show only fair recovery and are left with significant deficits.  The remaining one-third show no recovery at all, with marked dependence on others for basic functions of daily living.  New, more aggressive treatment protocols may result in greater recovery statistics.

What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to transverse myelitis in its laboratories at the National Institutes of Health (NIH), and also supports additional transverse myelitis research through grants to major medical institutions across the country.  Some studies focus on strategies to repair the spinal cord, including approaches using cell transplantation.  The NINDS also funds researchers who are using animal models of spinal cord injury to study strategies for replacement or regeneration of spinal cord nerve cells.  The knowledge gained from such research should lead to a greater knowledge of the mechanisms responsible for transverse myelitis and may ultimately provide a means to prevent and treat this disorder.

NIH Patient Recruitment for Transverse Myelitis Clinical Trials


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Transverse Myelitis Association
1787 Sutter Parkway
Powell, OH 43065-8806
Tel: 614-317-4884; 855-380-3330

American Chronic Pain Association (ACPA)
P.O. Box 850
Rocklin, CA 95677-0850
Tel: 916-632-0922; 800-533-3231
Fax: 916-652-8190

Miami Project to Cure Paralysis
P.O. Box 016960
Miami, FL 33101-6960
Tel: 305-243-6001; 800-STANDUP (782-6387)
Fax: 305-243-6017

National Rehabilitation Information Center (NARIC)
8400 Corporate Drive
Suite 500
Landover, MD 20785
Tel: 301-459-5900; 800-346-2742; 301-459-5984 (TTY)
Fax: 301-562-2401

The Guthy-Jackson Charitable Foundation
10525 Vista Sorrento Pkwy
Suite 210
San Diego, CA 92121
Tel: 858-638-7638
Fax: 858-638-7698

Related NINDS Publications and Information
  • Transverse Myelitis Fact Sheet
    Transverse Myelitis fact sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
  • Mielitis transversa
    Información sobre mielitis transversa/Spanish-language fact sheet on transverse mielitis compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Publicaciones en Español

Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892

NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.

Last Modified June 24, 2015