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Traumatic Brain Injury Press Releases

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New NIH-funded memory drug moves into Phase 1 clinical study
Thursday, Dec 31, 2015
An experimental drug that may improve memory is now being tested in a Phase 1 safety trial. The compound, BPN14770, was developed by Tetra Discovery Partners, with support from the NIH Blueprint Neurotherapeutics Network, a program designed to facilitate the discovery and development of novel neurological treatments. It is the first compound funded by the program to reach a Phase 1 clinical trial.

Thalamus tunes the brain activity

Scientists manipulate consciousness in rats
Friday, Dec 18, 2015
Scientists showed that they could alter brain activity of rats and either wake them up or put them in an unconscious state by changing the firing rates of neurons in the central thalamus, a region known to regulate arousal. The study, published in eLIFE, was partially funded by the National Institutes of Health.


NIH invests $85 million for BRAIN Initiative research
Thursday, Oct 1, 2015
The National Institutes of Health announced its second wave of grants to support the goals of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, bringing the NIH investment to $85 million in fiscal year 2015.

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Progesterone does not significantly improve outcome after traumatic brain injury
Tuesday, Jun 16, 2015
Results of a phase 3 randomized, placebo-controlled clinical trial suggest that progesterone may not significantly improve outcomes in patients who have suffered a moderate to severe traumatic brain injury.

NINDS Director Walter J. Korozhetz

NIH Names Walter J. Koroshetz, M.D. Director of the National Institute of Neurological Disorders and Stroke
Thursday, Jun 11, 2015
National Institutes of Health Director Francis S. Collins, M.D., Ph.D. announced today the selection of Walter J. Koroshetz, M.D., as the Director of the National Institute of Neurological Disorders and Stroke (NINDS). He has served as Acting Director of the NINDS since October, 2014.

Flicking internal brain switches on and off

Scientists use lasers to control mouse brain switchboard
Thursday, Aug 14, 2014
Ever wonder why it’s hard to focus after a bad night’s sleep? Using mice and flashes of light, scientists show that just a few nerve cells in the brain may control the switch between internal thoughts and external distractions. The study, partly funded by the National Institutes of Health, may be a breakthrough in understanding how a critical part of the brain, called the thalamic reticular nucleus (TRN), influences consciousness.

New NIH logo

NIH and NFL tackle concussion research
Monday, Dec 16, 2013
The National Institutes of Health has selected eight projects to receive support to answer some of the most fundamental problems on traumatic brain injury, including understanding long-term effects of repeated head injuries and improving diagnosis of concussions.

Effects of concussion on the human brain

Concussion secrets unveiled in mice and people
Sunday, Dec 8, 2013
There is more than meets the eye following even a mild traumatic brain injury. While the brain may appear to be intact, new findings reported in Nature suggest that the brain’s protective coverings may feel the brunt of the impact.

Autoinjector used in RAMPART

Autoinjectors offer way to treat prolonged seizures
Wednesday, Feb 15, 2012
Drug delivery into muscle using an autoinjector, akin to the EpiPen used to treat serious allergic reactions, is faster and may be a more effective way to stop status epilepticus, a prolonged seizure lasting longer than five minutes, according to a study sponsored by NIH. Status epilepticus is a potentially life-threatening emergency, and is usually treated with anticonvulsant drugs delivered intravenously.

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Members of new Interagency Pain Research Coordinating Committee announced
Monday, Feb 13, 2012
NIH announced the members of the new Interagency Pain Research Coordinating Committee chaired by NINDS Director Story Landis, Ph.D. The IPRCC includes researchers, members of nonprofit public advocacy organizations, and representatives from 7 federal agencies that deal with pain research and patient care.

CT scans show differences among six types of traumatic brain injury.

NIH database will speed research toward better prevention, diagnosis and treatment of TBI
Monday, Aug 29, 2011
NIH, in partnership with the Department of Defense, is building the Federal Interagency Traumatic Brain Injury Research (FITBIR) database. The database is expected to accelerate research toward better treatment and diagnosis of TBI by making it easier to compare results across studies.

DTI scans show thinning of tracts in the orbitofrontal white matter. Modified from Mac Donald et al. NEJM, 2011 Supplementary Appendix.

Diffusion Tensor Imaging May Shed Light on Soldiers' Brain Injuries
Wednesday, Jul 13, 2011
More than a hundred thousand soldiers have returned from combat in the Middle East with traumatic brain injuries. Despite devastating consequences, many of these injuries are difficult to see on brain scans. In a new study, researchers found that a method called diffusion tensor imaging (DTI) may be more sensitive than conventional scans for detecting signs of brain damage in these cases.

A DTI scan shows the many nerve fiber tracts that run through a healthy brain (viewed face-on).  The tracts look like mutlti-colored threads that fill in the outline of a brain.

Diffusion Tensor Imaging May Improve Diagnosis and Tracking of Mild Traumatic Brain Injuries
Thursday, Mar 4, 2010
Investigators have found that a state-of-the-art brain imaging method may be useful for detecting and monitoring mild traumatic brain injury, a controversial diagnosis that is based largely on a patient’s subjective experience. A mild traumatic brain injury typically involves no sign of damage based on a neurological exam or standard brain imaging techniques.

Motor Skill Learning May be Enhanced by Mild Brain Stimulation
Monday, Jan 19, 2009
People who received a mild electrical current to a motor control area of the brain were significantly better able to learn and perform a complex motor task than those in control groups.

An Over-Worked, Under-Appreciated Brain Cell Finally Gets its Due
Tuesday, Mar 11, 2008
As the cells that generate the brain's electrical signals, neurons tend to grab the limelight when it comes to studies of brain function. Until recently, brain cells called glia have been mostly ignored, and their roles remain poorly understood, despite the fact that they outnumber neurons by about 10 to 1.

Is It Just a Headache? Study Links Migraine to Brain Damage in Mice
Friday, Nov 16, 2007
Migraine headaches are a source of disabling pain for millions of people.  Now, a study in mice suggests that these headaches may be linked to tiny areas of stroke-like brain damage.  The findings suggest that treatment to prevent migraines may also prevent longer-term cognitive problems.

Imaging Neural Progenitor Cells in the Living Human Brain
Thursday, Nov 8, 2007
For the first time, investigators have identified a way to detect neural progenitor cells (NPCs), which can develop into neurons and other nervous system cells, in the living human brain using a type of imaging called magnetic resonance spectroscopy (MRS). The finding, supported by the National Institutes of Health (NIH), may lead to improved diagnosis and treatment for depression, Parkinson's disease, brain tumors, and a host of other disorders.

NIH National Neurology Advisory Council Gains Five New Members
Friday, Oct 12, 2007
The National Institute of Neurological Disorders and Stroke (NINDS) welcomes five new members to its National Advisory Neurological Disorders and Stroke Council. The Council serves as the principal advisory body to the NINDS, a component of the National Institutes of Health and the nation's primary supporter of basic, translational, and clinical research on the brain and nervous system.

Disease May Push Nerve Cells to Their Breaking Point, Literally
Tuesday, May 8, 2007
In some neurological diseases, neurons might die in a surprising, yet relatively simple way: by breaking under mechanical strain.

Doubling Up: Researchers Combine a Common Dietary Supplement with an Antibiotic to Treat Lou Gehrig's Disease
Friday, Jan 31, 2003
A new study shows that combining the supplement creatine and the antibiotic minocycline significantly slows disease progression and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.
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Minocycline Delays Onset and Slows Progression of ALS in Mice
Thursday, May 2, 2002
The antibiotic minocycline delays onset and slows progression of symptoms in a mouse model for amyotrophic lateral sclerosis (ALS), a new study shows. The study also revealed that the drug may work by blocking release of a molecule that triggers cell death. The findings may lead to new ways of treating ALS or other neurodegenerative disorders.
Fact Sheet

Turning Blood into Brain: New Studies Suggest Bone Marrow Stem Cells Can Develop into Neurons in Living Animals
Thursday, Nov 30, 2000
For years, researchers studying stem cells have been intrigued by the possibility that these cells might be used to treat brain diseases. Recent studies have suggested that neural stem cells transplanted into the brain can migrate throughout the brain and develop into other types of cells. Now, two new studies show that bone marrow cells transplanted into mice can migrate into the brain and develop into cells that appear to be neurons. The studies suggest that bone marrow may be a readily available source of neural cells with potential for treating such neurological disorders as Parkinson's disease and traumatic brain injury.