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Combining MRI and PET Could Yield Dynamic Pictures of the Brain
Friday, Apr 25, 2008
In experiments on mice, scientists report that they have successfully combined two brain imaging techniques – magnetic resonance imaging (MRI) and positron emission tomography (PET).

New Mouse Model for Neurofibromatosis Yields Insights into Disease Process and Treatment
Monday, Apr 21, 2008
In a move expected to enhance the development of therapies for neurofibromatosis type 1, scientists have created an improved mouse model for the disease.

NIH to Host Research Symposium on Clinical Applications of Stem Cell Therapies
Tuesday, Apr 1, 2008
"Challenges and Promise of Cell-Based Therapies" is a one-day symposium to explore promising research in regenerative medicine using stem cells.

Early Treatment Prevents Full-Blown Epilepsy in Animals
Friday, Mar 14, 2008
For the first time, researchers have shown that treating epilepsy-prone animals with an anticonvulsant drug prior to the development of chronic epilepsy can significantly reduce the number of seizures the animals experience, even after the treatment stops.  The study provides hope that researchers may eventually be able to prevent epilepsy in people who are at risk of the disorder because of genetic mutations or other factors.

Reactions to Protein Stress in Neurodegenerative Disease – Sometimes Good, Sometimes Bad and Always Ugly
Friday, Mar 14, 2008
Research has shown that cells have a cleanup system for handling protein "stress," and some studies suggest the possibility of developing therapeutic drugs that would work by giving the system a boost. But a new study published in Neuron suggests that during prolonged stress, the cleanup system can suppress vital cell functions or even actively kill the cell.

Leptin Inhibits Seizures; Study May Lead to New Treatments for Epilepsy
Thursday, Mar 13, 2008
A new study shows that leptin, a hormone normally associated with eating and metabolism, can inhibit seizures in animal models of epilepsy. The finding may lead to new ways of treating epilepsy. It also may help explain how the ketogenic diet, which is sometimes used to treat epilepsy, reduces seizures.

An Over-Worked, Under-Appreciated Brain Cell Finally Gets its Due
Tuesday, Mar 11, 2008
As the cells that generate the brain's electrical signals, neurons tend to grab the limelight when it comes to studies of brain function. Until recently, brain cells called glia have been mostly ignored, and their roles remain poorly understood, despite the fact that they outnumber neurons by about 10 to 1.

Study Identifies Possible Trigger for Parkinson's Disease
Monday, Feb 25, 2008
A chemical interaction that blocks cells' ability to break down damaged proteins may trigger development of Parkinson's disease (PD), a new study shows. Finding ways to overcome the blockage could lead to strategies for preventing the disease or stopping its progression.

NIH Announces New Initiative in Epigenomics
Tuesday, Jan 22, 2008
NIH Announces New Initiative in Epigenomics

Study Suggests Some Brain Injuries Reduce the Likelihood of Post-Traumatic Stress Disorder
Sunday, Dec 23, 2007
A new study of combat-exposed Vietnam War veterans shows that those with injuries to certain parts of the brain were less likely to develop post-traumatic stress disorder (PTSD). The findings, from the National Institutes of Health (NIH) and the National Naval Medical Center, suggest that drugs or pacemaker-like devices aimed at dampening activity in these brain regions might be effective treatments for PTSD.

NINDS Announces New Spanish-Language Website
Friday, Dec 7, 2007
Free, accurate information on many neurological disorders is now available on a new Spanish-language website from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH). The website is available at espanol.ninds.nih.gov.

El NINDS Anuncia una Nueva Página Web en Español
Friday, Dec 7, 2007
Información precisa y gratuita sobre muchos desordenes neurológicos esta ahora disponible en una nueva página web en español del National Institute of Neurological Disorders and Stroke (NINDS) el cual es parte de los National Institutes of Health (NIH). La página web se encuentra disponible en espanol.ninds.nih.gov.

The Structure of an Important Drug Target Made Crystal Clear
Wednesday, Dec 5, 2007
Scientists have produced detailed 3-dimensional images of a common type of neurotransmitter receptor, the class of proteins on the receiving end of chemical signals in the nervous system. The work, funded by the National Institutes of Health (NIH), is expected to speed the development of drugs for a variety of neurological and psychiatric disorders.

New Technique Removes Toxic Protein and Prevents Memory Impairment in Alzheimer's Disease Model
Wednesday, Dec 5, 2007
Increasing the activity of a key protein in the bloodstream slows the buildup of a toxic substance in the brains of mice with the gene mutation for Alzheimer's disease (AD). It also prevents some memory problems, a new study shows. If the approach works in humans, it may eventually lead to a way of preventing or halting AD.

Study Suggests Idebenone May Improve Neurological Function in Friedreich's Ataxia
Wednesday, Dec 5, 2007
Results of a placebo-controlled, double-blind phase II study of the antioxidant idebenone in children with Friedreich's ataxia (FA) suggest that the treatment may lead to improvements in neurological function. It is the first placebo-controlled study to suggest that the neurological deterioration associated with this disease can be slowed or reversed.

A photo of a rhesus macaque searching for pests on a mate.

Embryonic Stem Cell Milestone Achieved in Primates
Monday, Dec 3, 2007
Researchers have achieved a major milestone in embryonic stem cell research: they isolated embryonic stem cells for the first time from a cloned primate embryo. The technique, if developed in humans, could potentially be used to make personalized stem cells to treat diseases without worry of rejection by the patient’s immune system.

A Rollercoaster of Seizure-Like Activity May Damage the Alzheimer's Brain
Tuesday, Nov 27, 2007
Although seizures are not a common symptom of Alzheimer's disease (AD), the brains of people with AD could be humming with seizure-like activity, interrupted by quiet rebound periods that do more harm than good.

Cilia Malfunction Disrupts Brain Development: Study Helps Explain Joubert Syndrome, Other Disorders
Friday, Nov 16, 2007
What goes wrong in developmental brain disorders? Recent genetic studies have suggested a surprising culprit in some of these disorders: abnormalities in hairlike structures called cilia on the surfaces of cells. A new study shows that proteins associated with cilia are essential for normal development of the brain’s cerebellum. The finding helps to explain a diverse and puzzling group of developmental disorders.

Is It Just a Headache? Study Links Migraine to Brain Damage in Mice
Friday, Nov 16, 2007
Migraine headaches are a source of disabling pain for millions of people.  Now, a study in mice suggests that these headaches may be linked to tiny areas of stroke-like brain damage.  The findings suggest that treatment to prevent migraines may also prevent longer-term cognitive problems.

Scientists Zero in on the Cellular Machinery that Enables Neurons to Fire
Wednesday, Nov 14, 2007
If you ever had a set of Micronauts – toy robots with removable body parts – you probably had fun swapping their heads, imagining how it would affect their behavior. Scientists supported by the National Institutes of Health have been performing similar experiments on ion channels – pores in our nerve cells – to sort out the channels' key functional parts.

Imaging Neural Progenitor Cells in the Living Human Brain
Thursday, Nov 8, 2007
For the first time, investigators have identified a way to detect neural progenitor cells (NPCs), which can develop into neurons and other nervous system cells, in the living human brain using a type of imaging called magnetic resonance spectroscopy (MRS). The finding, supported by the National Institutes of Health (NIH), may lead to improved diagnosis and treatment for depression, Parkinson's disease, brain tumors, and a host of other disorders.

Neurons in the hippocampus of a Brainbow transgenic mouse

A Brain of Many Colors
Thursday, Nov 1, 2007
Using a clever genetic trick to generate dozens of different colors, researchers have for the first time visualized hundreds of cells and their connections to each other in the brain. Over the past few years, researchers have developed variations of proteins called fluorescent proteins that can appear in many different colors. Researchers reasoned that they might be able to use these proteins to generate a range of different colors in cells in the same way that a television or computer monitor can create almost unlimited colors by mixing red, green and blue.

NIH National Neurology Advisory Council Gains Five New Members
Friday, Oct 12, 2007
The National Institute of Neurological Disorders and Stroke (NINDS) welcomes five new members to its National Advisory Neurological Disorders and Stroke Council. The Council serves as the principal advisory body to the NINDS, a component of the National Institutes of Health and the nation's primary supporter of basic, translational, and clinical research on the brain and nervous system.

Treatment Blocks Pain Without Disrupting Other Functions
Wednesday, Oct 3, 2007
A combination of two drugs can selectively block pain-sensing neurons in rats without impairing movement or other sensations such as touch, according to a new study by National Institutes of Health (NIH)-supported investigators. The finding suggests an improved way to treat pain from childbirth and surgical procedures. It may also lead to new treatments to help the millions of Americans who suffer from chronic pain.

Arthritis Drug Shows Promise for Reducing Brain Hemorrhage in Premature Babies
Monday, Aug 27, 2007
A drug that is commonly used to reduce the pain of arthritis may eventually be used in pregnant women with preterm labor to lessen the risk of brain damage in very low birthweight babies, a new study suggests.

Gene Triggers Obsessive Compulsive Disorder-Like Syndrome in Mice: Study Suggests New Treatment Targets
Wednesday, Aug 22, 2007
Using genetic engineering, researchers have created an obsessive-compulsive disorder (OCD) - like set of behaviors in mice and reversed them with antidepressants and genetic targeting of a key brain circuit. The study, by National Institutes of Health (NIH) -funded researchers, suggests new strategies for treating the disorder.

The National Institute of Neurological Disorders and Stroke Announces Effort to Promote Stroke Awareness in the Hispanic Community
Wednesday, Aug 8, 2007
The National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health (NIH), announced the launch of a new community education program, which broadens the Institute’s national stroke education campaign "Know Stroke. Know the Signs. Act in Time." to promote stroke awareness among Hispanics in the United States.

Blood Pressure Drug May Slow Parkinson's Disease
Friday, Aug 3, 2007
For decades, scientists have tried to learn what causes the death of a select group of nerve cells in the brains of people with Parkinson's disease (PD). New research identifies an unusual mode of activity in these cells that makes them exceptionally vulnerable to toxins and stress and shows that a common drug can protect these neurons in animal models of PD. This work suggests a possible new way to slow or prevent the disease.

Support Cells Trigger Neuron Death in ALS
Thursday, Aug 2, 2007
Star-shaped support cells in the brain secrete a toxin that kills motor neurons in a model of amyotrophic lateral sclerosis (ALS), two new studies show.  The studies may lead to new ways of diagnosing and treating the disorder.

Lithium May Offer Relief from Rare but Devastating Neurological Disorders
Thursday, Aug 2, 2007
Lithium carbonate, a compound commonly used to treat depression, might also provide symptomatic relief for a group of inherited movement disorders that includes the fatal disease spinocerebellar ataxia type 1 (SCA1).

After a Decades-Long Search, Scientists Identify New Genetic Risk Factors for Multiple Sclerosis
Sunday, Jul 29, 2007
A pair of large-scale genetic studies supported by the National Institutes of Health has revealed two genes that influence the risk of getting multiple sclerosis (MS) – data sought since the discovery of the only other known MS susceptibility gene decades ago. The findings could shed new light on what causes MS – a puzzling mix of genes, environment and immunity – and on potential treatments for at least 350,000 Americans who have the disease.

A Basic Recipe for Prions
Monday, Jul 2, 2007
Prions have been among the most controversial of infectious disease agents. These misshapen proteins have no DNA or RNA, so many researchers have been skeptical of the idea that they alone can be responsible for disease. Now, infectious prions have successfully been created in the laboratory for the first time, providing insight into how these deadly proteins form.

Scientists Identify a Mouse Embryonic Stem Cell More Like Our Own
Thursday, Jun 28, 2007
Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem (ES) cells, the National Institutes of Health (NIH) announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.

Therapeutics for Huntington's and Related Diseases Could Pack a One-Two Punch
Tuesday, Jun 5, 2007
Added to its devastating neurological symptoms, Huntington's disease (HD) carries with it a lesser-known horror. The genetic mutation that causes the disease can grow larger, causing its symptoms – involuntary movements, dementia, and dramatic personality changes – to grow worse across generations and even during a single lifetime. New research sheds light on how the mutation grows and offers hope for locking it down.

NIH Study Tracks Brain Development in Some 500 Children across U.S.
Friday, May 18, 2007
Children appear to approach adult levels of performance on many basic cognitive and motor skills by age 11 or 12, according to a new study coordinated by the National Institutes of Health (NIH).

Blood-Clotting Protein Could be a Target for Therapy against MS
Monday, May 14, 2007
In multiple sclerosis (MS), the immune cells that patrol our blood for pathogens venture out of the bloodstream and attack the brain. Researchers have found that leakage of a blood-clotting protein into the brain, once considered merely a sign of damage in the MS brain, helps stimulate this attack.

Morality and the Brain: Is Choosing the Greater Good Rational or Just Cold?
Thursday, May 10, 2007
You are adrift at sea in a lifeboat weighed down with too many people, including a wounded man who is near death. Do you throw him overboard? Throughout history, philosophers have debated these kinds of moral dilemmas. Now, neuroscientists are joining the discussion, but instead of asking how we should make moral choices, they're asking how our brains actually make such choices.

Immune Cells Protect Against Alzheimer’s Disease
Wednesday, May 9, 2007
Immune cells in the brain help slow the accumulation of beta-amyloid that is a hallmark of Alzheimer’s disease (AD), a new study shows. The researchers also found that a specific immune system protein strongly affects mortality in a mouse model of AD.

Disease May Push Nerve Cells to Their Breaking Point, Literally
Tuesday, May 8, 2007
In some neurological diseases, neurons might die in a surprising, yet relatively simple way: by breaking under mechanical strain.

'Gateway' Gene Allows Brain Stem Cells to Grow into Tumors
Friday, Apr 6, 2007
According to a new study, a gene that supports normal brain development also supports the growth of a brain tumor called glioblastoma.

Inner Workings of the Magnanimous Mind
Wednesday, Apr 4, 2007
It’s an enduring mystery that taunts neuroscientists and evolutionary biologists. If the human brain evolved to maximize its owner’s survival, why are we motivated to help others, even when it incurs some personal cost?

Large-Scale Gene Study Identifies Clues about Sporadic ALS
Tuesday, Apr 3, 2007
Researchers at the National Institutes of Health (NIH) have completed the first large-scale study of the role of common genetic variation in sporadic amyotrophic lateral sclerosis (ALS), which occurs in people without any family history of the disease. The results provide interesting hints about the causes of the disorder and can serve as a starting point for future studies.

‘Gene Chip’ Study Could Lead to Blood Test for Parkinson’s
Monday, Apr 2, 2007
A new study has revealed 30 genes whose activity levels are altered in the blood of people with Parkinson’s disease (PD), paving the way for a blood test and a better understanding of what causes the disease.

NIH Announces Phase III Clinical Trial of Creatine for Parkinson's Disease
Thursday, Mar 22, 2007
The NIH National Institute of Neurological Disorders and Stroke (NINDS) is launching a large-scale clinical trial to learn if the nutritional supplement creatine can slow the progression of Parkinson's disease (PD). While creatine is not an approved therapy for PD or any other condition, it is widely thought to improve exercise performance. The potential benefit of creatine for PD was identified by Parkinson’s researchers through a new rapid method for screening potential compounds.

Better Prediction Could Mean Better Control over Epileptic Seizures
Tuesday, Mar 13, 2007
Despite conventional wisdom that epileptic seizures are random and unforeseeable, a new study shows that people can sometimes anticipate them, hinting at the possibility of treatments that could quell an oncoming seizure.

Sure You're Awake? Spit into this Cup
Friday, Mar 9, 2007
A study published in the Proceedings of the National Academy of Sciences identifies a chemical in saliva whose levels go up when people are sleep-deprived and down when they are rested.

Trigger for Adult Brain Disease May Be Set During Brain Development
Monday, Mar 5, 2007
A new study suggests that spinocerebellar ataxia type 1 (SCA1) – a genetic brain disease that manifests during adulthood – begins with subtle problems in brain development that occur during infancy.

Stem Cells Make Neurons, and Tumors, in Rat Model of Parkinson's Disease
Thursday, Mar 1, 2007
In a new study that illustrates the promise and perils of stem cell therapy, scientists found that implanting human embryonic stem cells led to dramatic functional improvement – but also to brain tumors – in a rat model of Parkinson’s disease (PD).

Brain Implant Teaches Neurons New Tricks
Monday, Feb 26, 2007
Using an electronic implant, researchers have altered the connections between cells in the motor control region of the monkey brain, subtly altering the cells’ influence over movement. Similar devices might one day be used to “rewire” damaged parts of the human brain and restore movement to people paralyzed by traumatic injury or neurological disease.

New Targets Found for Drug Development in Neuropathic Pain
Thursday, Feb 22, 2007
New studies reveal that two proteins in the body play a role in neuropathic pain – pain and sensitivity from a nerve injury that persist long after the nerve has healed. By zeroing in on these proteins, scientists hope to develop better drugs for the condition.

A picture of two white mice on a blue surface.  The left mouse appears approximately twice the size of the right one and is able to stand upright.  The right mouse is much smaller and appears to be leaning slightly.

Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Thursday, Feb 22, 2007
Drug therapy can extend survival and improve movement in a mouse model of spinal muscular atrophy (SMA), new research shows. The study, carried out at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS), suggests that similar drugs might one day be useful for treating human SMA.

Variation in HIV Protein Yields Clues to AIDS-Related Dementia
Thursday, Feb 8, 2007
In a move that could lead to better treatments for neurological complications of AIDS, researchers have identified a protein variant in HIV that is associated with brain infection and dementia in people with the disease.

Low Serum Vitamin D Linked to Multiple Sclerosis
Wednesday, Jan 31, 2007
A new study shows that multiple sclerosis (MS) is linked to low levels of vitamin D in the blood, but it’s unclear whether vitamin D deficiency is a causal factor in the disease or whether vitamin D supplements would protect against it.

Aggressive Brain Cancer Is Tied to Stem Cells ‘Gone Bad’
Monday, Jan 29, 2007
The existence of rogue stem cells that refuse to die explains why an aggressive brain tumor known as glioblastoma typically isn’t extinguished by radiation therapy. A study in the December 7, 2006 issue of Nature* shows that the therapy fails to kill a small but potent fraction of cancerous cells – about 5 percent of those in the tumor.

NIH Study Finds MRI More Sensitive Than CT in Diagnosing Most Common Form of Acute Stroke
Friday, Jan 26, 2007
Results from the most comprehensive study to compare two imaging techniques for the emergency diagnosis of suspected acute stroke show that magnetic resonance imaging (MRI) can provide a more sensitive diagnosis than computed tomography (CT) for acute ischemic stroke. The difference between MRI and CT was attributable to MRI’s superiority for detection of acute ischemic stroke—the most common form of stroke, caused by a blood clot. The study was conducted by physicians at the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health (NIH). Findings appear in the January 27, 2007 edition of The Lancet.

NINDS Names Dr. Walter Koroshetz as Deputy Director
Wednesday, Jan 3, 2007
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), has named Walter J. Koroshetz, M.D., as its Deputy Director. Effective January 2, 2007, he will work with the NINDS Director in program planning and budgeting, as well as oversee Institute scientific and administrative functions.

Developing Tools to Detect Cognitive Impairment from Silent Strokes
Monday, Nov 6, 2006
Scientists from the National Institute of Neurological Disorders and Stroke (NINDS) and the Canadian Stroke Network recently wrapped up a workshop – the first of its kind – aimed at harmonizing clinical and research tools for assessing vascular cognitive impairment (VCI), a common disability linked to stroke.

Gene Variants Linked to Risk of Stroke in Young Women
Monday, Nov 6, 2006
Specific variants of a gene called phosphodiesterase 4D (PDE4D) significantly increase the risk of stroke in women aged 15-49, a new study shows. The risk is magnified in women who smoke cigarettes. The study is the first to identify a possible interaction between this gene and an environmental factor in triggering stroke. The results help to show how the gene contributes to stroke risk and may lead to new ways of preventing stroke.

Enzyme Reverses Memory Loss in Alzheimer’s Mouse Model
Monday, Nov 6, 2006
Increasing the amount of a specific enzyme in the brain partially restores memory in a mouse model for Alzheimer’s disease (AD), researchers say. The results could eventually lead to new treatments for AD or other neurodegenerative disorders.

In Most Comprehensive Study Yet, Two-Week Regimen Helps Stroke Survivors Regain Arm Control
Tuesday, Oct 31, 2006
In the largest, most comprehensive study of its kind to date, researchers supported by the National Institutes of Health (NIH) showed clinical improvements out to one year when stroke survivors who had lost function in one arm were given a unique, two-week rehabilitation regimen.

Vitamin B3 Points Toward New Strategy For Treating MS
Friday, Oct 27, 2006
Researchers have shown that a form of vitamin B3 is beneficial in mice with an MS-like disease. Although standard doses of the vitamin would not be potent enough for long-term treatment of MS, the findings could be a step toward developing effective drugs against the disease.

Gene Variation Affects Pain Sensitivity and Risk of Chronic Pain: Finding May Lead to New Treatments
Sunday, Oct 22, 2006
A new NIH-funded study shows that a specific gene variant in humans affects both sensitivity to short-term (acute) pain in healthy volunteers and the risk of developing chronic pain after one kind of back surgery. Blocking increased activity of this gene after nerve injury or inflammation in animals prevented development of chronic pain.

Six New Members Named to National Neurology Advisory Council
Thursday, Oct 5, 2006
The National Institute of Neurological Disorders and Stroke (NINDS) has appointed six new members to its major advisory panel, the National Advisory Neurological Disorders and Stroke Council. The NINDS, a component of the National Institutes of Health (NIH), is the nation’s primary supporter of basic, translational, and clinical research on the brain and nervous system. NINDS Director Story Landis, Ph.D., formally introduced the new members, who will serve through July 2010, at the Council’s September 14, 2006 meeting.

NINDS Names New Scientific Director: Dr. Alan Koretsky to Lead Institute’s Intramural Research Program
Friday, Sep 29, 2006
The National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health (NIH), announces the appointment of Alan P. Koretsky, Ph.D., as Scientific Director.  Beginning October 1, 2006, he will direct the NINDS Division of Intramural Research, which conducts studies on the biomedical processes involved in the more than 600 disorders and conditions that affect the nervous system.

Researchers Announce Results of Study on Genetic Variation in Parkinson's Disease
Wednesday, Sep 27, 2006
Researchers at the National Institutes of Health (NIH) have completed one of the first large-scale studies of the role of common genetic variation in Parkinson’s disease (PD). While the results fill in some missing pieces of the genetic puzzle, they are primarily of benefit as a starting point for more detailed studies. The information generated by the study is now publicly available in a database that will serve as a valuable research tool for the future.

Researchers Identify Role of Protein Important for Stem Cell Growth; Study Leads to Recovery in Animal Model of Stroke
Wednesday, Aug 30, 2006
For the first time, researchers have found that a protein signal important in embryonic development promotes survival and proliferation of stem cells. Stimulating receptors for this protein, called Notch, led to functional recovery in rats with brain damage from stroke. The results suggest potential new ways of treating stroke and neurodegenerative diseases.

Organized Protein Network Discovered in the Ataxias
Monday, Aug 14, 2006
Scientists have recently announced discovery of a sophisticated network of interacting proteins that forms the basis for inherited neurodegenerative diseases such as the ataxias. This network gives scientists new insight into the normal function of disease-related genes. It also provides possible candidate sites for targeted therapies aimed at the ataxias and other progressive neurological disorders.

Mutant Mice Exhibit Abnormal Social Interactions and Brain Changes; Possible Animal Model for Autism Spectrum Disorders
Monday, Aug 14, 2006
A new study shows that inactivating a gene called Pten in a mouse model produces disturbances in social interaction and brain organization that closely mirror human autism and related disorders.  This is the first time scientists have developed an animal model with both behavioral and cellular abnormalities similar to autism.  These animals could provide important insights into understanding the brain regions and neurochemical interactions that underlie in this mysterious disease.

Double-Agent MMP-9: Timing is Everything in Stroke Treatment
Thursday, Aug 3, 2006
In a surprise twist, researchers have learned that a type of enzyme that contributes to brain damage immediately after a stroke also plays a role in brain remodeling and movement of neurons days after stroke. Understanding the secondary role for this enzyme in healing stroke damage may lead to new treatments for stroke and offer a longer window of time for treatment.

New Neurons are Born: Animal Model of Premature Babies Shows Evidence of Neuronal Recovery After Brain Injury
Wednesday, Jul 12, 2006
Research funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) shows that mice with a brain injury similar to that of many premature babies can generate new neurons that help to repair the damage. The study is the first to show that substantial recovery from neonatal injury can occur in the developing brain. The finding helps to explain why many children born prematurely with very low birth weight are able to overcome their early difficulties.

Javits Neuroscience Award Presented to Six Leading Scientists
Wednesday, Jul 12, 2006
Six outstanding scientists who target neurological disorders at the cellular and molecular level were recently awarded the prestigious Senator Jacob Javits Award in the Neurosciences. The award provides for up to seven years of research funding from the National Institute of Neurological Disorders and Stroke (NINDS), the nation’s leading agency for research on the brain and nervous system and a component of the National Institutes of Health.

Dopamine Drug Leads to New Neurons and Recovery of Function in Rat Model of Parkinson's Disease
Tuesday, Jul 4, 2006
In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases.

Neurons Grown From Embryonic Stem Cells Restore Function In Paralyzed Rats
Tuesday, Jun 20, 2006
For the first time, researchers have enticed transplants of embryonic stem cell-derived motor neurons in the spinal cord to connect with muscles and partially restore function in paralyzed animals. The study suggests that similar techniques may be useful for treating such disorders as spinal cord injury, transverse myelitis, amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy. The study was funded in part by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS).

Drug Prevents Brain Swelling After Stroke
Wednesday, Jun 14, 2006
A drug long used to treat diabetes significantly reduces brain swelling, neuron loss, and death after stroke in rats, researchers have found. The finding may lead to improved ways of treating stroke and other disorders in humans.

Study Finds Loss of Small Nerve Fibers in Complex Regional Pain Syndrome (CRPS)
Friday, May 19, 2006
A new study shows that a reduction in small-diameter nerve fibers is evident in the devastating chronic pain syndrome known as complex regional pain syndrome-type I (CRPS-I), which was formerly known as reflex sympathetic dystrophy. This finding of nerve damage could provide a biomarker, or a specific physical trait, that clinicians could use in the future to help diagnose and measure the natural history of CRPS.

Study Identifies Protein that Impairs Memory in Model for Alzheimer's Disease
Thursday, May 11, 2006
For the first time, researchers have identified a specific form of amyloid beta protein that causes memory impairment long before amyloid plaques and neurodegeneration appear in a mouse model of Alzheimer's disease (AD). The finding may lead to new ways of diagnosing and possibly even preventing the disease.

Economic Benefit of NINDS-Supported Clinical Trials Estimated at More Than $15 Billion Over Ten Years
Thursday, Apr 20, 2006
A comprehensive review of all phase III clinical trials supported by one Federal agency finds that, estimated conservatively, the economic benefit in the United States from just eight of these trials exceeded $15 billion over the course of 10 years. The study also found that new discoveries from the trials were responsible for an estimated additional 470,000 healthy years of life. The clinical trials were sponsored by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS).

New Orthostatic Hypotension Treatment Reduces Symptoms Without Causing High Blood Pressure
Tuesday, Apr 11, 2006
A drug traditionally used to treat myasthenia gravis shows potential benefit for reducing symptoms of orthostatic hypotension without raising blood pressure when people lie down, according to results of a double-blind, controlled clinical trial.

Opening the Window of Opportunity: Neuregulin-1 Protects Neurons from Stroke Hours after the Event
Wednesday, Mar 8, 2006
Stroke is the third leading cause of death in adults in the United States. Currently, the only approved drug treatment for acute stroke must be given within 3 hours from stroke onset. A recent study shows that a naturally occurring growth factor, called neuregulin-1, can protect nerve cells and decrease inflammation in an animal model of stroke when administered as long as 13 hours after the brain attack. This is the first study to show that neuregulin-1 can have a positive effect on the outcome after stroke in animals and could lead to new drug treatments for people.

Evaluation of Patients Treated With Natalizumab Finds No New Cases of Progressive Multifocal Leukoencephalopathy
Wednesday, Mar 1, 2006
An independent clinical and laboratory study of more than 3000 people treated with the drug natalizumab (Tysabri®) for multiple sclerosis (MS), Crohn’s disease, and rheumatoid arthritis has found no evidence of new cases of the often-fatal disorder called progressive multifocal leukoencephalopathy (PML). The laboratory component of the study was coordinated by the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH), working in conjunction with the NIH Clinical Center.

DCDC2: Demystifying and Decoding Dyslexia
Tuesday, Feb 28, 2006
A recent study shows that variations in a gene called DCDC2 may disrupt the normal formation of brain circuits that are necessary for fluent reading, leading to dyslexia. After further research, genetic screening for these variations could identify affected children early in their lives and possibly prevent the misdiagnosis of other learning disabilities that resemble dyslexia.

Study Implicates Potassium Channel Mutations in Neurodegeneration and Mental Retardation
Sunday, Feb 26, 2006
For the first time, researchers have linked mutations in a gene that regulates how potassium enters cells to a neurodegenerative disease and to another disorder that causes mental retardation and coordination problems. The findings may lead to new ways of treating a broad range of disorders, including Alzheimer's and Parkinson's diseases. The study was funded in part by the National Institutes of Health's National Institute of Neurological Disorders and Stroke (NINDS).

Preliminary Results Shows Creatine and Minocycline May Warrant Further Study in Parkinson’s Disease
Thursday, Feb 23, 2006
A National Institutes of Health-sponsored clinical trial with 200 Parkinson's disease patients has shown that creatine and minocycline may warrant further consideration for study in a large trial.

Advancements in Symptomatic and Neuroprotective Treatments Highlighted at First World Parkinson Congress
Thursday, Feb 23, 2006
At today’s World Parkinson Congress, the first international gathering of Parkinson’s researchers, health professionals, patients, and caregivers, some of the world’s leading neuroscientists from the United States, Canada, and Sweden presented on innovative therapies that show promise in controlling the symptoms of Parkinson’s, restoring lost function, and even altering the progression of the disease.

Expectations of Pain: I Think, Therefore I Am
Wednesday, Feb 15, 2006
While the theory that “mind over matter” exists is an ancient belief, the scientific studies to support this idea have remained elusive. A new study provides brain imaging evidence that positive thinking interacts with and shapes the sensory experience of pain. This study suggests that decreasing the expectation of pain can reduce both the pain-related brain activity and perception of pain intensity. This knowledge may lead to new and effective ways to manage chronic pain.

Study Finds Biochemical Defect in Juvenile Batten Disease
Wednesday, Jan 25, 2006
For the first time, scientists studying a fatal childhood neurodegenerative disorder, juvenile Batten disease, have identified a defect in transport of the amino acid arginine in cells from affected children. The finding helps researchers understand how the disease develops and may lead to new ways of treating it.

Study Links Alzheimer's Disease to Abnormal Cell Division
Tuesday, Jan 17, 2006
A new study in mice suggests that Alzheimer's disease (AD) may be triggered when adult neurons try to divide. The finding helps researchers understand what goes wrong in the disease and may lead to new ways of treating it.

EvoPrinter: New Tool for Finding Evolutionary Conserved DNA Sequences
Thursday, Dec 15, 2005
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have developed a computer search tool that rapidly compares DNA sequences among animal species to identify those sequences that have not changed during evolution. Studies shows that these identified DNA fragments are often essential to gene function.

Scientists Discover First Gene for Tourette Syndrome
Thursday, Dec 15, 2005
A team of scientists has discovered the first gene mutation that may cause some cases of Tourette syndrome (TS), an inherited neuropsychiatric disorder known for involuntary muscle and vocal tics.

Epilepsy Can Be Triggered by Support Cells in the Brain
Thursday, Dec 15, 2005
For decades, researchers have tried to understand what triggers clusters of neurons to begin signaling excessively in epilepsy. A new study shows that, in many cases, the answer resides in star-shaped support cells called astrocytes. The finding may lead to new ways of treating epilepsy.

Study Links Progressive Aphasia Syndrome to Prion Gene
Monday, Nov 28, 2005
Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene variants, a new study shows. The study is the first to link the prion protein gene to this disorder. The researchers also looked at the prion protein gene in people with Alzheimer's disease and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and did not find any association with specific gene variants in those disorders.

Genetic Analysis of Glioblastoma Brain Tumors Can Aid in Treatment Decisions, Study Shows
Wednesday, Nov 9, 2005
Screening glioblastoma brain tumors for two gene variations can reliably predict which tumors will respond to a specific class of drugs, a new study shows. The findings may lead to improved treatment for this devastating disease.

Chemical Messenger Inactivates Cellular "Police" in Multiple Sclerosis
Friday, Oct 28, 2005
One of the fundamental mysteries of autoimmune diseases is how normally protective immune responses go bad. A new study sheds some light on this issue by showing that a chemical messenger called interleukin 12, or IL-12, allows some white blood cells to proliferate and damage healthy tissues. This finding may lead to new drug treatments for multiple sclerosis (MS) and other autoimmune diseases.

Study Identifies New Mode of Action for Ataxia Gene
Wednesday, Oct 19, 2005
For the first time, researchers have identified how the gene for a hereditary neurodegenerative disease called spinocerebellar ataxia type 1 (SCA1) disables an important group of neurons in the brain. The findings improve understanding of how SCA1 and related diseases develop and may lead to new ways of treating them.

Toxic Interactions from Neighboring Cells May Be Necessary for Huntington’s disease
Tuesday, Sep 27, 2005
A new study suggests that interactions between different cells are critical for the development of Huntington’s disease (HD) and perhaps other neurodegenerative diseases. This study provides the first genetic evidence that cell-cell interactions may be a necessary step in the onset of HD symptoms in a mouse model. This knowledge may lead to new therapeutic strategies to treat HD.

Drug Screening Study Suggests New Treatments for Alzheimer's
Monday, Sep 26, 2005
While several treatments are currently available for Alzheimer's disease (AD), none of them can slow or halt the course of this devastating disorder. In a new study, researchers have now identified three compounds that inhibit an enzyme believed to be involved in the process that leads to AD. This discovery may lead to new treatments that can stop the disease process in its tracks.

New Members Appointed to National Neurology Advisory Council
Wednesday, Sep 14, 2005
U.S. Department of Health and Human Services Secretary Michael O. Leavitt announces three new appointments and one reappointment to the National Advisory Neurological Disorders and Stroke Council, the major advisory panel of the National Institute of Neurological Disorders and Stroke (NINDS). The NINDS, a component of the National Institutes of Health (NIH), is the nation’s primary supporter of basic, translational, and clinical research on the brain and nervous system. NINDS Director Story Landis, Ph.D., will introduce the new members, who will serve through July 2009, at the Council’s September 15, 2005 meeting.

NINDS Javits Award Goes to Six Inventive Neuroscientists
Wednesday, Sep 7, 2005
The National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health, has named six scientists to receive its prestigious Senator Jacob Javits Award in the Neurosciences. The award is given to individual investigators who have demonstrated exceptional scientific excellence and productivity in research supported by the NINDS and who are expected to conduct innovative research over the next 7 years.

NINDS Launches Stroke Awareness Video for Hispanics
Tuesday, Aug 30, 2005
Each year, more than 700,000 Americans have a stroke. Stroke is the third leading cause of death and the leading cause of long-term disability in the U.S. The disease also disproportionately affects Hispanics. According to the Centers for Disease Control and Prevention, Hispanics 35-64 years old are 1.3 times more likely to have a stroke than whites in the same age group. Today, the National Institute of Neurological Disorders and Stroke (NINDS) released a Spanish video designed to educate Hispanic communities nationwide about stroke prevention and treatment.

Stroke Information for Seniors Added to the NIHSeniorHealth Web Site
Tuesday, Aug 23, 2005
To help older adults learn more about the signs and symptoms of stroke and the need to act quickly, the National Institutes of Health is adding four new topics on stroke to its NIHSeniorHealth web site: Act Quickly, Warnings Signs and Risk Factors, What Happens during a Stroke, and Treatments and Research. The site features easy-to-read stroke information, developed by the National Institute of Neurological Disorders and Stroke (NINDS), and may be found at www.nihseniorhealth.gov.

Combination Therapy Leads to Partial Recovery from Spinal Cord Injury in Rats
Tuesday, Jul 26, 2005
Combining partially differentiated stem cells with gene therapy can promote the growth of new "insulation" around nerve fibers in the damaged spinal cords of rats, a new study shows. The treatment, which mimics the activity of two nerve growth factors, also improves the animals' motor function and electrical conduction from the brain to the leg muscles. The finding may eventually lead to new ways of treating spinal cord injury in humans.

Gene Therapy Relieves Neuropathic Pain in Rats
Tuesday, Jun 28, 2005
Using a weakened herpes virus to deliver a neurotransmitter-related gene to sensory neurons alleviates pain for up to 6 weeks in rats with chronic pain caused by nerve damage, a new study shows. The findings may lead to the first effective treatment for people affected by this type of "neuropathic" pain.

Silencing Gene Activity Prevents Disease in Model for Huntington's
Tuesday, Jun 7, 2005
Silencing the activity of a mutant gene prevents disease symptoms in a mouse model for Huntington's disease (HD), a new study shows. The study is the first to directly target the underlying problem that causes HD, and it may lead to a new way of treating this disorder.

TorsinA Protein Protects Against Neuron Loss in Model for Parkinson's Disease
Wednesday, Jun 1, 2005
A protein found naturally in the brain may protect against Parkinson's disease (PD), a new study shows. The findings also may lead to an improved understanding of a disorder called early-onset torsion dystonia.

First Genetic Screen Reveals Possible Gene Loci for Neural Tube Defects
Monday, May 9, 2005
Dozens of investigators studying nearly 300 individuals from 44 families nationwide have narrowed down the hunt for genes that may cause such birth defects as spina bifida and anencephaly.

Learning New Rules about the "Primitive" Brain
Wednesday, May 4, 2005
A new study sheds light on how people quickly learn associations such as “stop at red” or “go at green”. This study challenges the current view of how specific brain areas help us learn rules and behave accordingly. The findings help to reveal how the brain organizes and orders its functions and processes, systems that may be disrupted in disorders such as schizophrenia and autism.

NINDS Announces New Javits Neuroscience Investigator Awardees
Wednesday, May 4, 2005
Four prominent investigators were recently awarded the prestigious Senator Jacob Javits Award in the Neurosciences, which provides for up to seven years of research funding from the National Institute of Neurological Disorders and Stroke (NINDS).

New Gene Therapy Vector May Lead to Treatment for Muscular Dystrophy
Monday, Apr 18, 2005
One of the biggest challenges in developing useful gene therapy is finding a way to get the beneficial gene into enough cells of the body to effectively treat the disease. Now, researchers have shown in rodents that a virus called adeno-associated virus 8 (AAV8) can effectively deliver a gene to all the skeletal muscles of the body. If it works the same way in humans, this virus-based approach may allow the first effective gene therapy for muscular dystrophy (MD) and similar diseases.

Aspirin is Safer than Warfarin and Just as Effective for Treating Blocked Arteries in the Brain
Wednesday, Mar 30, 2005
To reduce the risk of stroke, partial blockage of arteries in the brain (intracranial stenosis) has for decades been treated with drugs such as aspirin and warfarin that reduce blood clotting. However, doctors have never had good evidence for choosing one therapy over the other. Now, results of a double-blind, randomized clinical trial show for the first time that aspirin works as well as warfarin with fewer side effects.

Statins Prevent a "Sticky" Situation in the Formation of Plaques
Wednesday, Mar 9, 2005
Studies have suggested that statins, a class of cholesterol-lowering drugs, may also lower the risk for Alzheimer’s disease (AD). A new study now suggests that some of the beneficial effects of the drug may be derived from a cholesterol-independent activity. This research, performed in mouse cells carrying an AD-causing gene mutation, may help scientists understand the clinical benefits of statins in AD.

TROY: A Newly Identified Stop Signal in the Pathway for Nerve Regeneration
Wednesday, Mar 9, 2005
One of the major puzzles in neuroscience is how to get nerves in the brain and spinal cord to regrow after injury. A new study has identified a protein, TROY, that inhibits nerve cell repair and plays a role in preventing nerve regeneration. This finding is an important step in developing new methods for treatment of spinal cord injury, stroke, and degenerative nerve disorders such as multiple sclerosis (MS).

Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy
Thursday, Mar 3, 2005
New research suggests that an off-the-market pain reliever called indoprofen may be a starting point for finding a new drug to treat spinal muscular atrophy (SMA), a devastating childhood neurological disorder.

Test Could Improve Detection of Prion Disease in Humans
Monday, Feb 14, 2005
A highly sensitive post-mortem test could help scientists more accurately determine if a person died of Creutzfeldt-Jakob disease (CJD), a human neurological disorder caused by the same class of infectious proteins that trigger mad cow disease, according to a new study supported in part by the National Institutes of Health (NIH). The finding opens the possibility that such testing might be refined in the future so it can be used to detect prion disease in living people and animals before the onset of symptoms.

Researchers Identify Joubert Syndrome Genes
Monday, Feb 7, 2005
Researchers have identified the genes for two different forms of Joubert syndrome, a rare developmental disorder that causes coordination and movement problems and mental retardation in children. The findings allow genetic testing for some forms of the disorder and provide valuable insights about how the human brain develops.

What's Old is New Again - Antibiotic Protects Nerves By Removing Excess Glutamate
Monday, Feb 7, 2005
A new study shows that a common antibiotic used to treat bacterial infections increases survival rates and delays nerve damage in a mouse model for amyotrophic lateral sclerosis (ALS). The antibiotic works by activating or "turning on" the gene encoding the glutamate transporter in neurons. This finding may lead to new drug treatments for ALS and other neurodegenerative diseases.

Serotonin Receptor Lets JC Virus Enter Brain Cells
Friday, Jan 14, 2005
Researchers funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the cellular receptor for the JC virus, which causes the fatal neurological disease progressive multifocal leukoencephalopathy (PML). Generic medicines currently available may be useful in preventing the infection.

Anti-Cholesterol Drug May Block Amyloid Pathology in Alzheimer’s Disease
Friday, Jan 14, 2005
A drug designed to inhibit cholesterol production may also block the production of amyloid, a hallmark of Alzheimer’s disease (AD). In a mouse model of the disease, the drug reduced amyloid buildup by up to 99 percent and worked for up to 2 months without any evidence of toxicity.

Ultrasound-aided Therapy Better Than Stroke Drug Alone, Trial Finds
Wednesday, Nov 17, 2004
Using ultrasound in combination with the drug t-PA can improve response to an ischemic stroke, according to a study involving 126 patients. This first-of-its-kind human trial compared the safety and efficacy of ultrasound and t-PA versus use of t-PA alone. The trial was funded in part by the National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health. The finding appears in the November 18, 2004, issue of the New England Journal of Medicine.

Internationally Acclaimed Pianist Gives Thanks to the National Institutes of Health for Innovative Treatment That Enabled His Comeback
Friday, Nov 12, 2004
Maestro Leon Fleisher, one of the world's most renowned classical pianists and three-time Grammy-nominee, will perform selections from his critically acclaimed new CD "Two Hands" at a pre-Thanksgiving event at the National Institutes of Health (NIH). More than 40 years ago, at the height of his career, Mr. Fleisher lost the use of his right hand to dystonia, the third most common neurological movement disorder after Parkinson's disease and essential tremor. He could no longer play the piano with both hands and the frequently misdiagnosed disorder severely impeded his performance of everyday tasks. About 10 years ago, physicians at the NIH were able to diagnose the problem as a focal dystonia and start him on a therapy which helped to reverse the condition.

Javits Neuroscience Investigator Award Recognizes Eight Exemplary Scientists
Wednesday, Nov 10, 2004
Eight noted investigators have been awarded the prestigious Senator Jacob Javits Award in the Neurosciences, which provides for up to seven years of research funding from the National Instittute of Neurological Disorders and Stroke (NINDS). The award, which honors the late U.S. Senator Jacob Javitz, is presented to investigators who have demonstrated exceptional scientific excellence and productivity in research aras supported by the NINDS and who are expected to conduct cutting-edge research over the next seven years.

NIH Neuroscience Blueprint to Shape Intra-Agency Research Cooperation
Sunday, Oct 24, 2004
National Institutes of Health Director Elias A. Zerhouni, M.D., today announced a new intra-agency partnership to accelerate neuroscience research. Dubbed the NIH Blueprint for Neuroscience Research, the agreement reinforces ongoing NIH efforts to increase collaborative research and information-sharing among 14 NIH Institutes and Centers that conduct or support research on the brain and nervous system.

A montage of four images of the development of a single neuron over a two-week period. The neuron was transfected with green flourescent protein and a microscope imaged the neuron 3 hours, 64 hours, 113 hours, and 137 hours later.

Study Using Robotic Microscope Shows How Mutant Huntington's Disease Protein Affects Neurons
Wednesday, Oct 13, 2004
Using a specially designed robotic microscope to study cultured cells, researchers have found evidence that abnormal protein clumps called inclusion bodies in neurons from people with Huntington's disease (HD) prevent cell death. The finding helps to resolve a longstanding debate about the role of these inclusion bodies in HD and other disorders and may help investigators find effective treatments for these diseases.
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Brain Imaging May Identify High Risk Stroke Patients
Thursday, Oct 7, 2004
By using sophisticated magnetic resonance imaging (MRI) technology, researchers have been able to study early changes in the blood-brain barrier (BBB), a semi-permeable membrane that surrounds and protects the brain, to predict a stroke patient's outcome. This study showed that the patients who had disruption in the BBB were more likely to experience bleeding in the brain and have a poor clinical outcome. The researchers say this technique could help identify patients who are most likely to do the best with thrombolytic therapy, and to help clinicians offer additional therapies to those who might suffer complications.
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Reorganization of the Brain Allows Blind Individuals to Process Speech More Effectively
Monday, Oct 4, 2004
The portion of the brain devoted to vision may play a prominent role in processing the spoken word in blind people. Research conducted by the NIH's National Institute of Neurological Disorders and Stroke (NINDS) shows that the "sight" region of the brain is essentially reorganized in blind individuals to help them process spoken words more effectively. The findings yield important information about the brain's ability to compensate for lost function.

Gene Silencing Prevents Brain Disease in Mice
Thursday, Sep 23, 2004
Scientists studying a mouse model of spinocerebellar ataxia 1 (SCA1) have found an effective way to "silence" the mutant gene allele or variant that causes the disorder while leaving the normal gene allele unaffected.
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Study in Dogs Shows that Histamine is Key to Wakefulness
Thursday, Sep 23, 2004
Scientists studying an animal model of narcolepsy have found that histamine-activated brain cells are key to wakefulness. The findings help to show why antihistamines, commonly used to treat colds and allergies, cause drowsiness and impair alertness.
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Gene for Rapid-Onset Dystonia Parkinsonism Found
Thursday, Sep 23, 2004
Investigators funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the gene responsible for a rare form of dystonia known as rapid-onset dystonia parkinsonism (RDP).
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Electrical Activity Alters Neurotransmitter Production in Frogs During Development
Tuesday, Aug 10, 2004
Scientists studying how the nervous system develops in frogs have found that altering the pattern of electrical signaling in individual neurons changes the kinds of neurotransmitters they produce. While preliminary, the finding may lead to a new understanding of how epilepsy and other neurological disorders develop and may even point to new ways of preventing or treating these disorders.

Vaccine Reduces Parkinson's Disease Neurodegeneration in Mice
Wednesday, Jul 28, 2004
For the first time, researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease. The finding suggests that a similar therapy might eventually be able to slow the devastating course of Parkinson's disease in humans.
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Study in Mice Links Growth Factor to Hereditary Motor Neuron Disease
Wednesday, Jul 7, 2004
Production of a growth factor in the spinal cord drops just before the onset of symptoms in an animal model of a rare, hereditary motor neuron disease, scientists have found. The findings point to a potential new way of treating this disease, and possibly other neurodegenerative disorders as well.
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Senataxin Gene Linked to Juvenile-Onset ALS
Wednesday, Jun 23, 2004
Researchers funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the gene that causes a rare juvenile-onset form of amyotrophic lateral sclerosis (ALS). The discovery of the Senataxin gene, on chromosome 9q34, may provide clues to the mechanisms of related brain disorders.
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Small Trial Shows Daclizumab Add-On Therapy Improves Multiple Sclerosis Outcome
Monday, May 24, 2004
A small clinical trial of patients with multiple sclerosis (MS) who did not respond to interferon alone found that adding the human antibody daclizumab improved patient outcome. Patients who received the combined therapy had a 78 percent reduction in new brain lesions and a 70 percent reduction in total lesions, along with other significant clinical improvements.
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Combination Therapy Dramatically Improves Function After Spinal Cord Injury in Rats
Sunday, May 23, 2004
A combination therapy using transplanted cells plus two experimental drugs significantly improves function in paralyzed rats, a new study shows. The results suggest that a similar therapy may be useful in humans with spinal cord injury.
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Study in Flies Allows Researchers to Visualize Formation of a Memory
Wednesday, May 12, 2004
For the first time, researchers have used a technique called optical imaging to visualize changes in nerve connections when flies learn. These changes may be the beginning of a complex chain of events that leads to formation of lasting memories.

Early Treatment Confirmed as Key to Stroke Recovery
Thursday, Mar 4, 2004
A study in the March 6, 2004, issue of The Lancet confirms the benefits of getting stroke patients to the hospital quickly for rapid thrombolytic treatment. The study provides the results of an extensive analysis of more than 2,700 stroke patients in six controlled clinical trials who were randomized for treatment with thrombolytic t-PA or a placebo.
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Valproic Acid Shows Promise for Treating Spinal Muscular Atrophy
Wednesday, Feb 18, 2004
One of the first studies of valproic acid as a potential therapy for spinal muscular atrophy (SMA) shows that, in cultured cells, the drug increases production of a protein that is reduced or missing in people with the disorder. While preliminary, the study suggests that valproic acid or related drugs may be able to halt or even reverse the course of this devastating childhood disease.
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Preconditioning the brain may protect against stroke
Tuesday, Jan 13, 2004
A December 2003 news article on genetic changes to protect the brain against a second larger stroke, prepared by the National Institute of Neurological Disorders and Stroke (NINDS).
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Yeast Model Yields Insight into Parkinson's Disease
Thursday, Dec 4, 2003
Scientists who developed the first yeast model of Parkinson's disease (PD) have been able to describe the mechanisms of an important gene's role in the disease. Tiago Fleming Outeiro, Ph.D., and Susan Lindquist, Ph.D., of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, studied the gene's actions under normal conditions and under abnormal conditions to learn how and when the gene's product, alpha-synuclein, becomes harmful to surrounding cells. The scientists created a yeast model that expresses the alpha-synuclein gene, which has been implicated in PD. Yeast models are often used in the study of genetic diseases because they offer researchers a simple system that allows them to clarify how genes work.
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Promising Gene Therapy Tool May Suppress Epileptic Seizures
Friday, Nov 14, 2003
A new gene therapy approach may one day stop seizures in people with common forms of epilepsy, according to a new study. Researchers found that the new therapy suppressed focal seizures and seizure induced brain damage in rats.
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Major New Finding on Genetics of Parkinson's Disease Zeroes In on Activity of Alpha Synuclein
Thursday, Oct 30, 2003
Scientists investigating a rare familial form of early-onset Parkinson's disease have discovered that too much of a normal form of the alpha-synuclein gene may cause Parkinson's disease. The finding, reported in the October 31, 2003, issue of Science, shows that abnormal multiplication of the alpha-synuclein gene can cause the disease.
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Study Reveals Patterns of Gene Activity in the Mouse Nervous System
Wednesday, Oct 29, 2003
The first published data from a government-funded project provide remarkable new insights into where specific genes are active in the mouse nervous system during development and adulthood. Information from this project will advance researchers' understanding of how particular genes function in the brain and spinal cord, leading to insights about how the nervous system works. It also may lead to new ways of preventing or treating disorders such as Parkinson's disease, Alzheimer's, psychiatric disorders, and drug addiction.

Investigators Explore Selective Silencing of Disease Genes
Wednesday, Oct 15, 2003
A new strategy to shut down mutant gene expression in the brain may someday be useful to treat a wide range of hereditary neurodegenerative diseases, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases.
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Study Links Restless Legs Syndrome to Poor Iron Uptake in the Brain
Monday, Aug 11, 2003
Results of the first-ever autopsy study of brains from people with restless legs syndrome (RLS) suggest that the disorder may result from inefficient processing of iron in certain brain cells. The findings provide a possible explanation for this disorder and may lead to new ways of treating the disease.
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Photo of Dr. Story Landis

Story C. Landis, Ph.D., Named New Director of the National Institute of Neurological Disorders and Stroke
Wednesday, Aug 6, 2003
Elias Zerhouni, M.D., director of the National Institutes of Health (NIH), today announced the appointment of Story C. Landis, Ph.D., as director of the National Institute of Neurological Disorders and Stroke (NINDS). Dr. Landis, who is currently the Scientific Director of the NINDS intramural program, will begin her appointment on September 1, 2003.

Study Provides New Information About Unruptured Brain Aneurysms
Monday, Jul 14, 2003
Results of the largest-ever international study of unruptured brain aneurysms provide a more comprehensive look at these vascular defects and offer guidance to patients and physicians facing the difficult decision about whether or not to treat an aneurysm surgically. The findings also suggest that the risk of rupture for most unrepaired small aneurysms (less than 7 millimeters in size) is small.
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Molecular Fingerprint Predicts HIV-Associated Dementia
Monday, Jun 23, 2003
A new study using a cutting edge research technique called "proteomics protein fingerprinting" shows that HIV patients with dementia have distinct protein patterns in their blood, setting them apart from patients with no symptoms of dementia. The study suggests a possible way to screen HIV patients for the first signs of cognitive impairment.
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Aspirin as Effective as Ticlopidine in African American Antiplatelet Stroke Prevention Study
Tuesday, Jun 10, 2003
Results from the African American Antiplatelet Stroke Prevention Study (AAASPS), a large multicenter trial of 1,809 African American stroke patients from over 60 sites in the United States, show that aspirin is as effective as ticlopidine for prevention of a second stroke in this population. Originally scheduled to run until October 2003, the AAASPS was stopped in July 2002, after analyses suggested that there was less than a 1% chance that ticlopidine would be shown to be superior to aspirin if the study were carried to completion.
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Faulty Muscle Repair Implicated in Muscular Dystrophies
Wednesday, May 21, 2003
Researchers have revealed what may be a totally new cause for muscular dystrophy (MD). A recent study shows that a protein defective in two types of late-onset MD plays a critical role in the normal repair of muscles.
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Misbehaving Molecules: 3-Dimensional Pictures of ALS Mutant Proteins Support Two Major Theories About How the Disease is Caused
Sunday, May 18, 2003
A new study reveals for the first time how gene mutations lead to the inherited form of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. The study suggests that the two most prominent theories of how familial ALS (FALS) and other related diseases develop are both right in part.
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Amid Ongoing Controversy, Researchers Find Opiates Relieve Chronic Pain From Nervous System Damage
Monday, May 12, 2003
A new study shows that opioid drugs taken orally could provide relief for some of the more than 2 million Americans suffering with chronic pain resulting from damage to the nervous system.
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Stroke Recovery Rates Slower for African Americans: New Research Examines Reasons for Racial Disparities
Thursday, May 8, 2003
African Americans are more likely to suffer strokes and recover from them at a slower rate than whites, and these differences are not simply the result of greater stroke severity. According to Ronnie D. Horner, Ph.D., program director at the National Institute of Neurological Disorders and Stroke (NINDS), and leader of a recently published study, research has found that African Americans who delay their post-stroke rehabilitation recover at a significantly slower rate than whites who experience the same rehabilitation delay. Recovery rates are even lower among low-income African Americans.
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What's in a Connection? A Look at Protein Patterns Within Synapses
Monday, May 5, 2003
A new study has begun to unravel the mysteries of protein interactions that govern the strength of nerve cell connections, or synapses, in the brain. The findings give researchers a better understanding of how synapses function during learning and memory, and they may lead to new insights about such neurological disorders as Parkinson's and Alzheimer's diseases.

Pressure Combined with Heat Reduces Prion Infectivity in Processed Meats
Monday, May 5, 2003
The combination of high temperature and very high pressure in the preparation of processed meats such as hot dogs and salami may effectively reduce the presence of infective prions while retaining the taste, texture, and look of these meats, according to a new study.
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Transport Problems Cause Motor Neuron Degeneration
Thursday, May 1, 2003
A new study shows for the first time in humans that nerve cell transport problems could play a key role in the degeneration of motor neurons, the nerve cells that control movement. The finding is an important step toward understanding the biology of motor neuron diseases and could lead to the development of effective treatments.
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Accurate and Affordable Diagnosis of Duchenne Muscular Dystrophy
Friday, Apr 18, 2003
Researchers have developed a simple and affordable blood test that detects the most common form of muscular dystrophy (MD) in more than 95 percent of cases.
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New Findings About Parkinson's Disease: Coffee and Hormones Don't Mix
Thursday, Apr 17, 2003
Several large studies have shown that caffeine intake is associated with a reduced risk of developing Parkinson's disease (PD) in men, but studies in women have been inconclusive. A new study shows that hormone therapy is a possible explanation for the different effects of caffeine on PD risk in men and women.
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A New Test for Myotonic Dystrophy: Exposing an Enemy That’s Too Big to See
Wednesday, Mar 26, 2003
Researchers have developed a genetic test that detects a common form of muscular dystrophy with 99 percent accuracy. The accurate diagnosis of myotonic muscular dystrophy type 2 (DM2) allows researchers to fully describe its clinical features for the first time.
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Dystonia Protein Linked to Problem Common in Other Neurological Disorders
Monday, Mar 24, 2003
A new study links the protein that is impaired in the movement disorder torsion dystonia to a problem that is common to many neurological diseases. The finding may point to new treatments for dystonia, Parkinson's disease, and other disorders.
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Cognitive Abilities Increase Significantly With Time in Most Prematurely Born Children
Tuesday, Feb 11, 2003
Many studies have found that children born prematurely with very low birthweight have an increased risk of neurological problems, including cognitive handicaps. New research shows that most of these children improve significantly on tests of cognitive function during early childhood and score within the normal range on tests of verbal comprehension and intelligence by age 8.

Doubling Up: Researchers Combine a Common Dietary Supplement with an Antibiotic to Treat Lou Gehrig's Disease
Friday, Jan 31, 2003
A new study shows that combining the supplement creatine and the antibiotic minocycline significantly slows disease progression and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.
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Drug-Resistant Seizures Often Take Years to Develop
Monday, Jan 27, 2003
While about 80 percent of people with epilepsy gain significant relief from drug therapy, the remaining 20 percent have seizures that cannot be controlled by medications. Many of these people have a particular type of epilepsy called partial epilepsy. A new study shows that people with partial epilepsy often have seizures controlled by medications for years before their seizures become drug-resistant. The study also found that periods when seizures stopped for a year or more are common in these patients.
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Bone Marrow Generates New Neurons in Human Brains
Monday, Jan 20, 2003
A new study strongly suggests that some cells from bone marrow can enter the human brain and generate new neurons and other types of brain cells. If researchers can find a way to control these cells and direct them to damaged areas of the brain, this finding may lead to new treatments for stroke, Parkinson's disease, and other neurological disorders.

Study Links Chronic Pain to Signals in the Brain
Tuesday, Jan 7, 2003
For centuries, doctors have tried to find effective ways to treat chronic pain, a devastating neurological disorder that affects almost 90 million Americans. A new study shows that two proteins in the brain trigger the neuronal changes that amplify and sustain this type of pain. The finding may lead to new ways of treating chronic pain.
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Old Drug, New Use: New Research Shows Common Cholesterol-Lowering Drug Reduces Multiple Sclerosis Symptoms in Mice
Monday, Jan 6, 2003
A new study shows that a widely prescribed cholesterol-lowering drug dramatically reduces symptoms of multiple sclerosis (MS) in mice. Results of the study suggest that statins, which are commonly used to prevent heart attack and stroke, could be a possible new treatment for MS and other autoimmune disorders.
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Tumor-Tracking Missiles: Researchers Develop a Possible New Treatment Strategy for Deadly Brain Tumors
Tuesday, Dec 31, 2002
In spite of advances in neurosurgery and radiation techniques, the prognosis for p