Schilder's disease is a rare progressive demyelinating disorder which usually begins in childhood. Schilder's disease is not the same as Addison-Schilder disease (adrenoleukodystrophy). Symptoms may include dementia, aphasia, seizures, personality changes, poor attention, tremors, balance instability, incontinence, muscle weakness, headache, vomiting, and vision and speech impairment. The disorder is a variant of multiple sclerosis. Treatment for the disorder follows the established standards in multiple sclerosis and includes corticosteroids, beta-interferon or immunosuppressive therapy, and symptomatic treatment. As with multiple sclerosis, the course and prognosis of Schilder's disease are unpredictable. For some individuals the disorder is progressive with a steady, unremitting course. Others may experience significant improvement and even remission. In some cases, Schilder's disease is fatal. The NINDS supports and conducts an extensive research program on demyelinating disorders such as Schilder's disease. Much of this research focuses on learning more about these disorders and finding ways to prevent, treat, and cure them. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&term=diffuse+cerebral+sclerosis+of+schilder+AND+human[mh]+AND+english[la]&db=PubMed&orig_db=PubMed&filters=on&pmfilter_EDatLimit=5+Years 1 http://clinicaltrials.gov/ct2/results?term= /disorders/schilders/pubs_schilders.htm /disorders/schilders/xml_schilders.xml xml_schilders.xml Myelinoclastic Diffuse SclerosisDiffuse Sclerosis V168 National Multiple Sclerosis Society

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3rd Floor New York NY 10017-3288 ContactUsNMSS@nmss.org http://www.nationalmssociety.org 212-986-3240 800-344-4867 (FIGHTMS) 212-986-7981 Funds research, helps families stay together, provides accurate and up-to-date information, helps with employment issues, offers free counseling, runs self-help groups, advocates for people with disabilities, and provides referrals to medical professionals. V165 Multiple Sclerosis Association of America

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Cherry Hill NJ 08002 webmaster@msassociation.org http://www.msassociation.org 856-488-4500 800-532-7667 856-661-9797 National, non-profit organization dedicated to enhancing the quality of life for those affected by multiple sclerosis. MSAA provides ongoing support and direct services to individuals with MS and their families and works to promote a greater understanding of the needs and challenges of those who face physical obstacles. V166 Multiple Sclerosis Foundation

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Ft. Lauderdale FL 33309-2130 support@msfocus.org http://www.msfocus.org 954-776-6805 888-MSFOCUS (673-6287) 954-351-0630 Dedicated to helping people with MS, the Multiple Sclerosis Foundation offers a wide array of free services including: national toll-free support, educational programs, homecare services, support groups, assistive technology programs, publications, a comprehensive website, and more programs to improve the quality of life for those affected by MS.