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NINDS Schilder's Disease Information Page

Synonym(s):   Myelinoclastic Diffuse Sclerosis, Diffuse Sclerosis

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What is Schilder's Disease?

Schilder's disease is a rare progressive demyelinating disorder which usually begins in childhood. Schilder's disease is not the same as Addison-Schilder disease (adrenoleukodystrophy). Symptoms may include dementia, aphasia, seizures, personality changes, poor attention, tremors, balance instability, incontinence, muscle weakness, headache, vomiting, and vision and speech impairment. The disorder is a variant of multiple sclerosis.

Is there any treatment?

Treatment for the disorder follows the established standards in multiple sclerosis and includes corticosteroids, beta-interferon or immunosuppressive therapy, and symptomatic treatment.

What is the prognosis?

As with multiple sclerosis, the course and prognosis of Schilder's disease are unpredictable. For some individuals the disorder is progressive with a steady, unremitting course. Others may experience significant improvement and even remission. In some cases, Schilder's disease is fatal.

What research is being done?

The NINDS supports and conducts an extensive research program on demyelinating disorders such as Schilder's disease. Much of this research focuses on learning more about these disorders and finding ways to prevent, treat, and cure them.

NIH Patient Recruitment for Schilder's Disease Clinical Trials


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National Multiple Sclerosis Society
733 Third Avenue
3rd Floor
New York, NY   10017-3288
Tel: 800-344-4867 (800-FIGHT-MS)
Fax: 212-986-7981

Multiple Sclerosis Association of America
706 Haddonfield Road
Cherry Hill, NJ   08002
Tel: 856-488-4500 800-532-7667
Fax: 856-661-9797

Multiple Sclerosis Foundation
6520 North Andrews Avenue
Ft. Lauderdale, FL   33309-2130
Tel: 954-776-6805 888-MSFOCUS (673-6287)
Fax: 954-351-0630

Related NINDS Publications and Information

Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892

NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.

Last updated July 17, 2015