Opsoclonus myoclonus is a rare neurological disorder characterized by an unsteady, trembling gait, myoclonus (brief, shock-like muscle spasms), and opsoclonus (irregular, rapid eye movements). Other symptoms may include difficulty speaking, poorly articulated speech, or an inability to speak. A decrease in muscle tone, lethargy, irritability, and malaise (a vague feeling of bodily discomfort) may also be present. Opsoclonus myoclonus may occur in association with tumors or viral infections. It is often seen in children with tumors. Treatment for opsoclonus myoclonus may include corticosteroids or ACTH (adrenocorticotropic hormone). In cases where there is a tumor present, treatment such as chemotherapy, surgery, or radiation may be required. The prognosis for opsoclonus myoclonus varies depending on the symptoms and the presence and treatment of tumors. With treatment of the underlying cause of the disorder, there may be an improvement of symptoms. The symptoms sometimes recur without warning. Generally the disorder is not fatal. The NINDS supports and conducts research on movement disorders such as opsoclonus myoclonus. These studies are aimed at increasing knowledge about these disorders and finding ways to prevent, treat, and cure them. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&term=opsoclonus+AND+human[mh]+AND+english[la]+AND+(review[ptyp]+OR+review+literature[mh]+OR+practice+guideline[ptyp]+OR+guideline[ptyp]+OR+clinical+trials[mh]+OR+clinical+trial[ptyp]+OR+consumerj[sb])&db=PubMed&orig_db=PubMed&filters=on&pmfilter_EDatLimit=2+Years 1 http://clinicaltrials.gov/ct2/results?term= /disorders/opsoclonus_myoclonus/pubs_opsoclonus_myoclonus.htm /disorders/opsoclonus_myoclonus/xml_opsoclonus_myoclonus.xml xml_opsoclonus_myoclonus.xml Kinsbourne syndromeMyoclonic Encephalopathy of InfantsDancing Eyes-Dancing Feet Syndrome V735 Opsoclonus Myoclonus Support Network, Inc.

2116 Casa Linda Dr.

West Covina CA 91791 626-315-8125 Serves as a resource center for opsoclonus myoclonus patients and health professionals, including physicians and researchers, and helps patients and their families to network with others affected by the syndrome. Any person affected by the syndrome is considered a community member. V91 National Organization for Rare Disorders (NORD)

55 Kenosia Avenue

Danbury CT 06810 orphan@rarediseases.org http://www.rarediseases.org 203-744-0100 Voice Mail 800-999-NORD (6673) 203-798-2291 Federation of voluntary health organizations dedicated to helping people with rare "orphan" diseases and assisting the organizations that serve them. Committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and service.