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Neurofibromatosis Press Releases


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Organ Transplant Drug Could Treat Meningioma
Thursday, Jun 11, 2009
Researchers funded by the National Institute of Neurological Disorders and Stroke (NINDS) have found that an organ transplant drug might one day be used to treat meningioma, a type of brain tumor. The drug also could be used to treat neurofibromatosis type 2, a rare disease associated with meningiomas and other benign tumors of the nervous system.

Researchers Identify Mechanism, Possible Drug Treatment for Tumors in Neurofibromatosis
Thursday, Oct 30, 2008
Researchers studying neurofibromatosis type 1 – a rare disease in which tumors grow within nerves – have found that the tumors are triggered by crosstalk between cells in the nerves and cells in the blood. They also found that a drug on the market for treating certain kinds of blood cancer curbs tumor growth in a mouse model of neurofibromatosis type 1.

New Mouse Model for Neurofibromatosis Yields Insights into Disease Process and Treatment
Monday, Apr 21, 2008
In a move expected to enhance the development of therapies for neurofibromatosis type 1, scientists have created an improved mouse model for the disease.

Researchers Identify Potential Treatment for Learning Disability in Neurofibromatosis
Wednesday, Jan 16, 2002
Researchers studying learning disabilities associated with neurofibromatosis type 1, or NF1, have traced the problem to excessive activity of a crucial signaling molecule and have successfully reversed the disabilities in mice by giving them an experimental drug. The findings provide hope that these learning problems may one day be treatable in humans.
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Second Gene Responsible for Tuberous Sclerosis Complex Identified; TSC1 Finding on Chromosome 9 Follows 1993 Discovery of TSC2 Gene
Thursday, Aug 7, 1997
Scientists have identified the second of two genes that cause tuberous sclerosis complex (TSC), a relatively common developmental disorder characterized by a number of abnormalities, including seizures, benign tumors in several organs, and variable emotional and cognitive disabilities. The discovery, to be reported in the August 8, 1997, issue of Science by David Kwiatkowski, M.D., Ph.D., and colleagues at Brigham and Women's Hospital in Boston, was funded by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Human Genome Research Institute (NHGRI), both components of the National Institutes of Health.

Scientists Isolate "Crown Jewel" — Huntington's Disease Gene
Tuesday, Mar 23, 1993
Scientists have identified the genetic mutation that causes Huntington's disease (HD), a fatal, neurodegenerative disorder characterized by progressive physical and mental deterioration. The discovery, to be reported in the March 26 issue of Cell,* is the culmination of a 10-year-long collaboration between investigators in six laboratory groups around the world with major support from the National Institute of Neurological Disorders and Stroke (NINDS).

NINDS Grantees Identify NF2 Gene; Gene Protects Against Nervous System Tumors
Thursday, Mar 11, 1993
Scientists have identified a gene that normally prevents development of tumors and, when damaged, causes an inherited disorder with multiple brain and spinal cord tumors called neurofibromatosis type 2 (NF2). Their results appear in the March 12 issue of Cell.

NINDS Scientists Isolate Segments Of DNA Sequence That Identify More Than 2,300 Brain Genes
Wednesday, Feb 12, 1992
Using a novel strategy, scientists from the National Institute of Neurological Disorders and Stroke have isolated segments of DNA sequence that uniquely identify more than 2,300 brain genes. The recent data, combined with data from 347 segments sequenced earlier by NINDS scientists, doubles the total number of human genes identified by sequencing, scientists report in the February 13 issue of Nature.

NINDS Scientists Develop Strategy To Speed Gene and Brain Research
Thursday, Jun 20, 1991
Using a novel strategy, scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have isolated key identifying regions of more than 400 genes that work inside the human brain. The scientists say their work should help identify genetic defects that cause brain disease and speed progress of genetics research.