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Brain P-gp and Inflammation in People with Epilepsy



Eligibility Criteria:

INCLUSION—

For people with epilepsy:

  • Have focal epilepsy.
  • Are 18-60 years of age.
  • Are able to give informed consent.
  • Must be enrolled in protocol 01-N-0139

For healthy volunteers

  • Are 18-60 years of age.
  • Are able to give informed consent.

EXCLUSION—

For people with epilepsy:

  • Have a previous radiation exposure (for example, from X-rays or other PET scans) that, together with the radiation exposure from this study would cause you to exceed the NIH research limits.
  • Have metal in your body which would make having an MRI scan unsafe.
  • Are uncomfortable in small closed spaces (have claustrophobia) so that you would feel uncomfortable in the MRI machine.
  • Cannot lie comfortably flat on your back for up to 2 hours in the MRI scanner and during the PET scans.
  • Have a brain disease in addition to epilepsy.
  • Are taking medications that interfere with P-gp function.
  • Have a serious medical illness based on our evaluation.
  • Have a brain abnormality on an MRI scan that we will perform.
  • Are pregnant or breast feeding.  Women of childbearing potential must agree to use an effective form of birth control until one week after all PET scan are completed.
  • Have blood cell that do not bind, which happens in about 10% of people.
  • Have drug or alcohol abuse or dependence.

For healthy volunteers

  • Have a previous radiation exposure (for example, from X-rays or other PET scans) that, together with the radiation exposure from this study would cause you to exceed the NIH research limits.
  • Have metal in your body which would make having an MRI scan unsafe.
  • Are uncomfortable in small closed spaces (have claustrophobia) so that you would feel uncomfortable in the MRI machine.
  • Cannot lie comfortably flat on your back for up to 2 hours in the MRI scanner and during the PET scans.
  • Have a brain disease including epilepsy.
  • Are taking medications that interfere with P-gp function.
  • Have a serious medical illness based on our evaluation.
  • Have a brain abnormality.
  • Are pregnant or breast feeding.  Women of childbearing potential must agree to use an effective form of birth control until one week after all PET scan are completed.
  • Have blood cells that do not bind, which happens in about 10% of people.
  • Have drug or alcohol abuse or dependence.
  • Have a positive test for illegal drugs.
  • Have any current Axis 1 diagnosis for psychiatric disease.

Last updated February 12, 2014