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Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures



Eligibility Criteria:

General inclusion criteria for PMD patients:

  • Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis must be made by a neurologist.
  • Able to give informed consent
  • Age 18 or older

General inclusion criteria for PNES patients:

  • Diagnosis of PNES based on recording of patient's typical episode during 24 h video-EEG without concomitant EEG changes. The diagnosis must be made by a neurologist.
  • Able to give informed consent
  • Age 18 or older

General exclusion criteria for PMD patients:

  • Significant neurological disorders (primary or comorbid) such as neurodegenerative disorders, stroke, movement disorders or epilepsy
  • Inflammatory disorders or autoimmune disorders active within the last 6 months
  • Patients with psychotic disorders or manic depression or active substance abuse within the last 6 months
  • Current suicidal ideation
  • Disease severity requiring inpatient treatment

Additional exclusion criteria for PMD patients for MRI:

  • Patients with movement symptoms at rest that may substantially inhibit resolution, comfort, or safety of MRI
  • Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations
  • History of traumatic brain injury with loss of consciousness or amnesia lasting greater than a few seconds
  • Contraindication to MRI
  • Pregnancy
  • Significant medical illness
  • Patients with current post-traumatic stress disorder, panic disorder or obsessive compulsive disorder
  • Patients on tricyclic antidepressants or antiepileptic medications 2 weeks prior to testing

General exclusion criteria for PNES patients:

  • Significant neurological disorders (primary or comorbid) such as neurodegenerative disorders, stroke, movement disorders or epilepsy
  • Inflammatory disorders or autoimmune disorders active within the last 6 months
  • Patients with psychotic disorders or active substance abuse within the last 6 months
  • Current suicidal ideation
  • Disease severity requiring inpatient treatment

Inclusion criteria for healthy volunteers:

  • Able to give informed consent
  • Age 18 or older

General exclusion criteria for healthy volunteers:

  • Significant neurological disorders (primary or comorbid) such as neurodegenerative disorders, stroke, movement disorders or epilepsy
  • History of DSM IV-defined schizophrenia, schizoaffective disorder, bipolar disorder or major depression with psychosis
  • History of psychotic disorders or manic depression or active substance abuse within the last 6 months
  • Subjects with post-traumatic stress disorder, obsessive compulsive disorder or panic disorder
  • Subjects on antidepressants or antiepileptic medications
  • Inflammatory disorders or autoimmune disorders active within the last 6 months

Additional exclusion criteria for healthy volunteers for MRI:

  • Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations
  • Contraindication to MRI
  • Pregnancy
  • Significant medical illness

Specific Exclusion Criteria for all subjects for HRV:

  • You take medications that affect your heart rate or rhythm
  • You have a history of heart disease

Last updated January 3, 2013