Brain Influsion of Muscimol to Treat Epilepsy

Eligibility Criteria:

INCLUSION:

1. Be 18 years of age or older.
2. Have simple or complex partial seizures.
3. Seizures must persist at 2 or more per month, despite medical therapy.
4. Be able to give informed consent.
5. Have been determined by the NIH neurology staff to have medically intractable epilepsy.
6. Have a seizure focus in a single region of one cerebral hemisphere.

EXCLUSION:

1. Are pregnant.
2. Have a contraindication to MRI scanning.
3. Have a bleeding disorder that cannot be corrected before testing or treatment.
4. Are unable to comprehend the risks of the testing and surgical therapy.
5. Have seizure foci in more than one region of one hemisphere or in both cerebral hemispheres.
6. Have a positive HIV test, because such patients would have increased risk of infection due to their immune deficiency.