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Amyotrophic Lateral Sclerosis (ALS) Publications
Genetic Lassos May Steer Neurons Toward Survival During Lou Gehrig's Disease
Cowboys use lassos to catch runaway horses and cattle. Recently, NINDS-funded researchers showed that genetic lassos may also be used to “round-up” toxic runaway molecules in neurons. Their results suggest that molecules, called RNA lariats, may effectively prevent nerve degeneration during amyotrophic lateral sclerosis.
New gene mutations linked to ALS and nerve cell growth dysfunction
Researchers have linked newly discovered gene mutations to some cases of the progressive fatal neurological disease amyotrophic lateral sclerosis – ALS, also known as Lou Gehrig’s disease. Shedding light on how ALS destroys the cells and leads to paralysis, the researchers found that mutations in this gene affect the structure and growth of nerve cells.
New model of ALS is based on human cells from autopsied tissue
By isolating cells from patients' spinal tissue within a few days after death, researchers funded by the National Institute of Neurological Disorders and Stroke have developed a new model of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. They found that during the disease, cells called astrocytes become toxic to nerve cells – a result previously found in mouse models of familial ALS. The new study shows that astrocytes derived from people with sporadic ALS are also toxic to neurons.