The septum pellucidum (SP) is a thin membrane located at the midline of the brain. Children who are born without this membraine and also have other abnormalities--pituitary deficiencies and abnormal development of the optic disk--have a disorder known as septo-optic dysplasia. More information about this condition can be located at the NINDS Septo-Optic Dysplasia Information Page.
Absence of the SP alone is not a disorder but is instead a characteristic noted in children with septo-optic dysplasia.
The absence of the septum pellucidum alone is not a disorder. However, when it is part of septo-optic dysplasia the prognosis varies according to the presence and severity of associated symptoms.
The NINDS conducts and supports a wide range of studies that explore the complex mechanisms of normal brain development. The knowledge gained from these fundamental studies provides the foundation for understanding how this process can go awry and, thus, offers hope for new means to treat and prevent developmental brain disorders.
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Last Modified October 30, 2015